VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT, Vít POSPÍŠIL, Filipp SAVVULIDI, Juraj KOKAVEC, Emanuel NEČAS, Adéla BERKOVÁ, Petra OBRTLÍKOVÁ, Josef KARBAN, Marek MRÁZ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Marek TRNĚNÝ, Jiří ZAVADIL and Tomáš STOPKA. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. Washington, DC , USA: American Society of Hematology, 2011, vol. 117, No 14, p. 3816-3825. ISSN 0006-4971. Available from: https://dx.doi.org/10.1182/blood-2010-05-285064. |
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@article{945694, author = {Vargová, Karin and Curik, Nikola and Burda, Pavel and Bašová, Petra and Kulvait, Vojtěch and Pospíšil, Vít and Savvulidi, Filipp and Kokavec, Juraj and Nečas, Emanuel and Berková, Adéla and Obrtlíková, Petra and Karban, Josef and Mráz, Marek and Pospíšilová, Šárka and Mayer, Jiří and Trněný, Marek and Zavadil, Jiří and Stopka, Tomáš}, article_location = {Washington, DC , USA}, article_number = {14}, doi = {http://dx.doi.org/10.1182/blood-2010-05-285064}, keywords = {MYB; CLL; miR-155 host gene; B-CLL}, language = {eng}, issn = {0006-4971}, journal = {Blood}, title = {MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia}, volume = {117}, year = {2011} }
TY - JOUR ID - 945694 AU - Vargová, Karin - Curik, Nikola - Burda, Pavel - Bašová, Petra - Kulvait, Vojtěch - Pospíšil, Vít - Savvulidi, Filipp - Kokavec, Juraj - Nečas, Emanuel - Berková, Adéla - Obrtlíková, Petra - Karban, Josef - Mráz, Marek - Pospíšilová, Šárka - Mayer, Jiří - Trněný, Marek - Zavadil, Jiří - Stopka, Tomáš PY - 2011 TI - MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia JF - Blood VL - 117 IS - 14 SP - 3816-3825 EP - 3816-3825 PB - American Society of Hematology SN - 00064971 KW - MYB KW - CLL KW - miR-155 host gene KW - B-CLL N2 - Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription. ER -
VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT, Vít POSPÍŠIL, Filipp SAVVULIDI, Juraj KOKAVEC, Emanuel NEČAS, Adéla BERKOVÁ, Petra OBRTLÍKOVÁ, Josef KARBAN, Marek MRÁZ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Marek TRNĚNÝ, Jiří ZAVADIL and Tomáš STOPKA. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. \textit{Blood}. Washington, DC , USA: American Society of Hematology, 2011, vol.~117, No~14, p.~3816-3825. ISSN~0006-4971. Available from: https://dx.doi.org/10.1182/blood-2010-05-285064.
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