Detailed Information on Publication Record
2011
Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice
DOUBEK, Michael, Jiří MAYER, Petra OBRTLÍKOVÁ, Lukáš SMOLEJ, Eduard CMUNT et. al.Basic information
Original name
Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice
Name in Czech
Moderní a konvenční prognostické markery u chronické lymfatické leukémie v každodenní hematologické praxi
Authors
DOUBEK, Michael (203 Czech Republic, guarantor, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Petra OBRTLÍKOVÁ (203 Czech Republic), Lukáš SMOLEJ (203 Czech Republic), Eduard CMUNT (203 Czech Republic), Jiří SCHWARZ (203 Czech Republic), Martin BREJCHA (203 Czech Republic), Petr KOZMON (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Yvona BRYCHTOVÁ (203 Czech Republic, belonging to the institution), Zdeněk POSPÍŠIL (203 Czech Republic, belonging to the institution) and Marek TRNĚNÝ (203 Czech Republic)
Edition
European Journal of Haematology, Kopenhagen, Munksgaard Int. Publ. 2011, 0902-4441
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Denmark
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.614
RIV identification code
RIV/00216224:14740/11:00065560
Organization unit
Central European Institute of Technology
UT WoS
000292778800005
Keywords in English
chronic lymphocytic leukemia;cytogenetics;IgVH mutation status;overall survival;prognostic markers
Tags
International impact, Reviewed
Změněno: 8/4/2014 06:56, Mgr. Nikola Kostlánová, Ph.D.
V originále
Objectives: The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS. TTT was significantly influenced by gender, Rai stage, IgVH status, 11q deletion, 17p deletion, 13q deletion and by CD38 expression. Multiparametric analysis revealed that OS was significantly influenced by gender, age, IgVH status, and 17p deletion. If only patients who died of CLL were included, gender, age, Rai stage, IgVH status, and deletion 17p had significant influence on OS. Based on our results, the examination of biological prognostic markers can give an insight into the possible disease evolution in daily clinical practice. Biological prognostic markers are however not ready (maybe except deletion 17p in younger patients) to be used for guidance of therapy at least outside of clinical trials.
In Czech
Význam moderních prognostických markeru pro klinický průběh chronické lymfatické leukémie v každodenní hematologické praxi ještě není stále dobře definován, především ne u velké skupiny pacientů. Proto cílem této studie bylo studium významu konvenčních a moderních prognostických markerů na celkové přežití a čas do terapie u pacientů s CLL. Retrospektivně jsme analyzovali data všech pacientů zařazených do databáze pěti velkých akademických center v české republice.
Links
| FR-TI2/254, research and development project |
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| MSM0021622430, plan (intention) |
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| NT11217, research and development project |
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| NT11218, research and development project |
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