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@article{945704,
author = {Doubek, Michael and Mayer, Jiří and Obrtlíková, Petra and Smolej, Lukáš and Cmunt, Eduard and Schwarz, Jiří and Brejcha, Martin and Kozmon, Petr and Pospíšilová, Šárka and Brychtová, Yvona and Pospíšil, Zdeněk and Trněný, Marek},
article_location = {Kopenhagen},
article_number = {2},
doi = {http://dx.doi.org/10.1111/j.1600-0609.2011.01639.x},
keywords = {chronic lymphocytic leukemia;cytogenetics;IgVH mutation status;overall survival;prognostic markers},
language = {eng},
issn = {0902-4441},
journal = {European Journal of Haematology},
title = {Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice},
url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2011.01639.x/pdf},
volume = {87},
year = {2011}
}
TY - JOUR
ID - 945704
AU - Doubek, Michael - Mayer, Jiří - Obrtlíková, Petra - Smolej, Lukáš - Cmunt, Eduard - Schwarz, Jiří - Brejcha, Martin - Kozmon, Petr - Pospíšilová, Šárka - Brychtová, Yvona - Pospíšil, Zdeněk - Trněný, Marek
PY - 2011
TI - Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice
JF - European Journal of Haematology
VL - 87
IS - 2
SP - 130-137
EP - 130-137
PB - Munksgaard Int. Publ.
SN - 09024441
KW - chronic lymphocytic leukemia;cytogenetics;IgVH mutation status;overall survival;prognostic markers
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2011.01639.x/pdf
L2 - http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2011.01639.x/pdf
N2 - Objectives: The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS. TTT was significantly influenced by gender, Rai stage, IgVH status, 11q deletion, 17p deletion, 13q deletion and by CD38 expression. Multiparametric analysis revealed that OS was significantly influenced by gender, age, IgVH status, and 17p deletion. If only patients who died of CLL were included, gender, age, Rai stage, IgVH status, and deletion 17p had significant influence on OS. Based on our results, the examination of biological prognostic markers can give an insight into the possible disease evolution in daily clinical practice. Biological prognostic markers are however not ready (maybe except deletion 17p in younger patients) to be used for guidance of therapy at least outside of clinical trials.
ER -
DOUBEK, Michael, Jiří MAYER, Petra OBRTLÍKOVÁ, Lukáš SMOLEJ, Eduard CMUNT, Jiří SCHWARZ, Martin BREJCHA, Petr KOZMON, Šárka POSPÍŠILOVÁ, Yvona BRYCHTOVÁ, Zdeněk POSPÍŠIL and Marek TRNĚNÝ. Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice. \textit{European Journal of Haematology}. Kopenhagen: Munksgaard Int. Publ., 2011, vol.~87, No~2, p.~130-137. ISSN~0902-4441. Available from: https://dx.doi.org/10.1111/j.1600-0609.2011.01639.x.
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