Type I iodothyronine 5’-deiodinase mRNA and activity is
increased in adipose tissue of obese subjects

J 2012

Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects

ORTEGA, F. J., Z. M. JÍLKOVÁ, J. M. MORENO-NAVARRETE, Stanislav PAVELKA, J. I. RODRIGUEZ-HERMOSA et. al.

Basic information

Original name

Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects

Name in Czech

mRNA a aktivita jodothyronin 5'-dejodasy typu I jsou zvýšené v tukové tkáni obézních jedinců

Authors

ORTEGA, F. J. (724 Spain), Z. M. JÍLKOVÁ (203 Czech Republic), J. M. MORENO-NAVARRETE (724 Spain), Stanislav PAVELKA (203 Czech Republic, guarantor, belonging to the institution), J. I. RODRIGUEZ-HERMOSA (724 Spain), Jan KOPECKÝ (203 Czech Republic) and J. M. FERNÁNDEZ-REAL (724 Spain)

Edition

International Journal of Obesity, London, NATURE PUBLISHING GROUP, 2012, 0307-0565

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.221

RIV identification code

RIV/00216224:14740/12:00059037

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/ijo.2011.101

UT WoS

000300321600019

Keywords (in Czech)

Tuková tkáň; tyreoidální hormony; dejodasy; tkáňová exprese; enzymová aktivita

Keywords in English

Adipose tissue; thyroid hormones; deiodinases; tissue expression; enzyme activity

Abstract

ORIG CZ

V originále

Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects.

In Czech

U skupiny 70 pacientů byla vyhodnocena úroveň exprese genů kódujících jodothyronin 5'-dejodasu typu I (D1), leptin (LEP) a stearoyl-CoA desaturasu 1 (SCD-1) v jejich omentálním (OM) a subkutánním (SC) tuku. U náhodně vybrané podskupiny 19 lidí byly rovněž stanoveny enzymové aktivity všech tří typů jodothyronin dejodas (D1, D2 a D3).

Links

MSM0021622413, plan (intention)

Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment

Citovat

ORTEGA, F. J., Z. M. JÍLKOVÁ, J. M. MORENO-NAVARRETE, Stanislav PAVELKA, J. I. RODRIGUEZ-HERMOSA, Jan KOPECKÝ and J. M. FERNÁNDEZ-REAL. Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects. International Journal of Obesity. London: NATURE PUBLISHING GROUP, 2012, vol. 36, No 2, p. 320-324. ISSN 0307-0565. Available from: https://dx.doi.org/10.1038/ijo.2011.101.

@article{945714,
   author = {Ortega, F. J. and Jílková, Z. M. and MorenoandNavarrete, J. M. and Pavelka, Stanislav and RodriguezandHermosa, J. I. and Kopecký, Jan and FernándezandReal, J. M.},
   article_location = {London},
   article_number = {2},
   doi = {http://dx.doi.org/10.1038/ijo.2011.101},
   keywords = {Adipose tissue; thyroid hormones; deiodinases; tissue expression; enzyme activity},
   language = {eng},
   issn = {0307-0565},
   journal = {International Journal of Obesity},
   title = {Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects},
   url = {http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html},
   volume = {36},
   year = {2012}
}

TY  - JOUR
ID  - 945714
AU  - Ortega, F. J. - Jílková, Z. M. - Moreno-Navarrete, J. M. - Pavelka, Stanislav - Rodriguez-Hermosa, J. I. - Kopecký, Jan - Fernández-Real, J. M.
PY  - 2012
TI  - Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
JF  - International Journal of Obesity
VL  - 36
IS  - 2
SP  - 320-324
EP  - 320-324
PB  - NATURE PUBLISHING GROUP
SN  - 03070565
KW  - Adipose tissue
KW  - thyroid hormones
KW  - deiodinases
KW  - tissue expression
KW  - enzyme activity
UR  - http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html
L2  - http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html
N2  - Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects.
ER  -

ORTEGA, F. J., Z. M. JÍLKOVÁ, J. M. MORENO-NAVARRETE, Stanislav PAVELKA, J. I. RODRIGUEZ-HERMOSA, Jan KOPECKÝ and J. M. FERNÁNDEZ-REAL. Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects. \textit{International Journal of Obesity}. London: NATURE PUBLISHING GROUP, 2012, vol.~36, No~2, p.~320-324. ISSN~0307-0565. Available from: https://dx.doi.org/10.1038/ijo.2011.101.

Detailed Information on Publication Record