HRDLIČKOVÁ, Barbara and Lydie IZAKOVIČOVÁ HOLLÁ. Relationship between 17q21 locus and adult asthma in Czech population. Human Immunology. Elsevier, 2011, vol. 72, No 10, p. 921-925. ISSN 0198-8859. Available from: https://dx.doi.org/10.1016/j.humimm.2011.07.309.
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Basic information
Original name Relationship between 17q21 locus and adult asthma in Czech population
Name in Czech Vztah mezi 17q21 lokusem a astmatem dospělých v české populaci
Authors HRDLIČKOVÁ, Barbara (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Human Immunology, Elsevier, 2011, 0198-8859.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30203 Respiratory systems
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.837
RIV identification code RIV/00216224:14110/11:00052770
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.humimm.2011.07.309
UT WoS 000295901100024
Keywords (in Czech) alergické astma; ORMDL3; jednonukleotidový polymorfizmus; SNP
Keywords in English Allergic asthma; ORMDL3; single nucleotide polymorphism; SNP
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 23/3/2012 13:33.
Abstract
Several whole-genome association studies have shown a significant link between childhood asthma and the 17q12 chromosome region. We selected tagging single nucleotide polymorphisms (SNPs) in the ORMDL3 gene (17q12) to investigate gene variability in relation to adult allergic asthma and asthma/atopy traits in the Czech Caucasians. Our findings suggest that the genetic variability in the 17q21 region may be one of the risk factors also for adult asthma, especially in males.
Abstract (in Czech)
Řada celogenomových studií ukázala signifikantní vztah mezi dětským astmatem a oblastí chromozomu 17q12. Vybrali jsme tzv. "tag" jednonukleotidové polymorfizmy (SNPs) v genu pro ORMDL3 (17q12) k analýze genové variability u alergického astmatu dospělých, resp. vztahu k atopii/atopickým fenotypům v české populaci. Naše výsledky naznačují, že genová variabilita lokusu 17q12 může být rizikovým faktorem také pro astma dospělých, zejména u mužů.
Links
MUNI/E/0002/2008, interní kód MUName: Genetická variabilita ORMDL3 - nového kandidáta genu astmatu - v české populaci (Acronym: GVOČP)
Investor: Masaryk University, Category E - centralized resources
2B06060, research and development projectName: Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu (Acronym: NPVII11002)
Investor: Ministry of Education, Youth and Sports of the CR
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