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@article{947060,
author = {Bouchal, Pavel and Vyhlídalová, Tereza and Struhárová, Iva and Zdráhal, Zbyněk and Kučera, Igor},
article_location = {Dordrecht, The Netherlands},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s12223-011-0007-3},
keywords = {Superoxide dismutase; Paracoccus denitrificans; azide; FNR regulators; proteomics},
language = {eng},
issn = {0015-5632},
journal = {Folia Microbiologica},
title = {Fe/Mn superoxide dismutase in Paracoccus denitrificans is induced by azide and expressed independently on FNR-type regulators},
url = {http://www.springerlink.com/content/d75727152265l4p0/},
volume = {56},
year = {2011}
}
TY - JOUR
ID - 947060
AU - Bouchal, Pavel - Vyhlídalová, Tereza - Struhárová, Iva - Zdráhal, Zbyněk - Kučera, Igor
PY - 2011
TI - Fe/Mn superoxide dismutase in Paracoccus denitrificans is induced by azide and expressed independently on FNR-type regulators
JF - Folia Microbiologica
VL - 56
IS - 1
SP - 13-17
EP - 13-17
PB - Springer
SN - 00155632
KW - Superoxide dismutase
KW - Paracoccus denitrificans
KW - azide
KW - FNR regulators
KW - proteomics
UR - http://www.springerlink.com/content/d75727152265l4p0/
N2 - In the facultatively anaerobic bacterium Paracoccus denitrificans, the synthesis of many proteins involved in energy metabolism is regulated by the FNR-type transcription factors (FnrP, NNR and NarR). One of them, NarR, senses nitrate or nitrite concentration and promotes expression of the membrane-bound nitrate reductase genes. It can also be activated by azide as a non-metabolizable analogue of nitrate. In this work we show that one of the most prominent protein species inducible by azide is a Fe/Mn-family superoxide dismutase (SOD). Azide induces SOD at protein, mRNA transcript and enzyme activity levels in the aerobically growing cells. Since SOD expression remains unaffected in the fnrP, nnr and narR mutant strains, we postulate a mechanism independent of the known FNR-type regulators but involving a redox signal arising from the respiratory chain.
ER -
BOUCHAL, Pavel, Tereza VYHLÍDALOVÁ, Iva STRUHÁROVÁ, Zbyněk ZDRÁHAL a Igor KUČERA. Fe/Mn superoxide dismutase in Paracoccus denitrificans is induced by azide and expressed independently on FNR-type regulators. \textit{Folia Microbiologica}. Dordrecht, The Netherlands: Springer, roč.~56, č.~1, s.~13-17. ISSN~0015-5632. doi:10.1007/s12223-011-0007-3. 2011.
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