Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

JUŘICA, Jan, Ondřej ZENDULKA, Roman TRUBAČ and Alexandra ŠULCOVÁ. Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver. Activitas Nervosa Superior Rediviva. Praha: Collegium Internationale Activitatis N.S, 2011, vol. 53, No 1, p. 32-34. ISSN 1337-933X.

Basic information

• Original name: Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver
• Name in Czech: Systémové podání D2 antagonisty raclopridu inhibuje CYP1A2 v potkaním modelu izolovaných perfundovaných jater
• Authors: JUŘICA, Jan (203 Czech Republic, guarantor, belonging to the institution), Ondřej ZENDULKA (203 Czech Republic, belonging to the institution), Roman TRUBAČ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Activitas Nervosa Superior Rediviva, Praha, Collegium Internationale Activitatis N.S, 2011, 1337-933X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Slovakia
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14740/11:00052906
• Organization unit: Central European Institute of Technology
• Keywords (in Czech): racloprid; cytochrom P450; izolovaná perfundovaná játra
• Keywords in English: raclopride; cytochrome P450; isolated perfused rat liver
• Tags: ok, rivok

Abstract

Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 is a rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek & Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.