J 2011

Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

JUŘICA, Jan, Ondřej ZENDULKA, Roman TRUBAČ and Alexandra ŠULCOVÁ

Basic information

Original name

Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

Name in Czech

Systémové podání D2 antagonisty raclopridu inhibuje CYP1A2 v potkaním modelu izolovaných perfundovaných jater

Authors

JUŘICA, Jan (203 Czech Republic, guarantor, belonging to the institution), Ondřej ZENDULKA (203 Czech Republic, belonging to the institution), Roman TRUBAČ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution)

Edition

Activitas Nervosa Superior Rediviva, Praha, Collegium Internationale Activitatis N.S, 2011, 1337-933X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14740/11:00052906

Organization unit

Central European Institute of Technology

Keywords (in Czech)

racloprid; cytochrom P450; izolovaná perfundovaná játra

Keywords in English

raclopride; cytochrome P450; isolated perfused rat liver

Tags

Změněno: 3/4/2012 01:00, Olga Křížová

Abstract

V originále

Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 is a rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek & Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.