Invasion of macrophages in the dorsal root ganglia of two neuropathic pain models.

KLUSÁKOVÁ, Ilona, Ivana HRADILOVÁ SVÍŽENSKÁ and Petr DUBOVÝ. Invasion of macrophages in the dorsal root ganglia of two neuropathic pain models. In Morphology 2011, Praha. 2011.

Basic information

• Original name: Invasion of macrophages in the dorsal root ganglia of two neuropathic pain models.
• Name in Czech: Invaze makrofágů do spinálního ganglia u dvou modelů neuropatické bolesti.
• Authors: KLUSÁKOVÁ, Ilona, Ivana HRADILOVÁ SVÍŽENSKÁ and Petr DUBOVÝ.
• Edition: Morphology 2011, Praha, 2011.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• Keywords in English: macrophages; chronic constriciton injury; spared nerve injury; dorsal root ganglion

Abstract

Activation of macrophages in response to the peripheral nerve injury is essential for both nerve regeneration and neuropathic pain induction. In this study we investigated whether intensity of macrophage invasion depends on type of neuronal injury. Invasion of ED-1+ macrophages was detected and quantified bilaterally in lumbar DRG using image analysis system 1 week after i/ chronic constriction injury (CCI) and ii/ spared nerve injury (SNI) of rat sciatic nerve. ED-1+ cell areas considered to be macrophages were found bilaterally in DRG 1 week after both types of nerve injury. Significantly higher proportion of ED-1+ cell areas was observed in the ipsilateral than contralateral DRG in both types of neuropathic pain models. In contrast to the CCI, SNI model displayed significantly higher proportion of ED-1+ suggesting massive infiltration of DRG by activated macrophages.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.