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@article{949469,
author = {Ráčil, Zdeněk and Burešová, Lucie and Brejcha, Martin and Procházková, Jiřina and Zounar, René and Timilsina, Shira and Rázga, Filip and Tošková, Martina and Cetkovský, Petr and Mayer, Jiří},
article_number = {9},
doi = {http://dx.doi.org/10.1002/ajh.22100},
keywords = {Clinical laboratory features; leukemia analysis},
language = {eng},
issn = {0361-8609},
journal = {American Journal of Hematology},
title = {Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients},
volume = {86},
year = {2011}
}
TY - JOUR
ID - 949469
AU - Ráčil, Zdeněk - Burešová, Lucie - Brejcha, Martin - Procházková, Jiřina - Zounar, René - Timilsina, Shira - Rázga, Filip - Tošková, Martina - Cetkovský, Petr - Mayer, Jiří
PY - 2011
TI - Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients
JF - American Journal of Hematology
VL - 86
IS - 9
SP - 800-803
EP - 800-803
PB - Wiley-Blackwell
SN - 03618609
KW - Clinical laboratory features
KW - leukemia analysis
N2 - To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had the shortest time to a definitive diagnosis (2 weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis, and the first such report that reflects on clinical practice in the new millennium.
ER -
RÁČIL, Zdeněk, Lucie BUREŠOVÁ, Martin BREJCHA, Jiřina PROCHÁZKOVÁ, René ZOUNAR, Shira TIMILSINA, Filip RÁZGA, Martina TOŠKOVÁ, Petr CETKOVSKÝ a Jiří MAYER. Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients. \textit{American Journal of Hematology}. Wiley-Blackwell, roč.~86, č.~9, s.~800-803. ISSN~0361-8609. doi:10.1002/ajh.22100. 2011.
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