Detailed Information on Publication Record
2011
Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients
RÁČIL, Zdeněk, Lucie BUREŠOVÁ, Martin BREJCHA, Jiřina PROCHÁZKOVÁ, René ZOUNAR et. al.Basic information
Original name
Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients
Name in Czech
Klinické a laboratorní charakteristiky leukémií v době diagnozy: Analýza 1,004 po sobě jdoucích pacientů
Authors
RÁČIL, Zdeněk (203 Czech Republic, guarantor, belonging to the institution), Lucie BUREŠOVÁ (203 Czech Republic, belonging to the institution), Martin BREJCHA (203 Czech Republic), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), René ZOUNAR (203 Czech Republic), Shira TIMILSINA (524 Nepal, belonging to the institution), Filip RÁZGA (703 Slovakia, belonging to the institution), Martina TOŠKOVÁ (703 Slovakia, belonging to the institution), Petr CETKOVSKÝ (203 Czech Republic) and Jiří MAYER (203 Czech Republic, belonging to the institution)
Edition
American Journal of Hematology, Wiley-Blackwell, 2011, 0361-8609
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.671
RIV identification code
RIV/00216224:14740/11:00053037
Organization unit
Central European Institute of Technology
UT WoS
000295003800019
Keywords in English
Clinical laboratory features; leukemia analysis
Tags
International impact
Změněno: 3/4/2012 02:16, Olga Křížová
V originále
To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had the shortest time to a definitive diagnosis (2 weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis, and the first such report that reflects on clinical practice in the new millennium.
In Czech
Za účelem určit hlavní rysy nejčastějších leukémií a popis období od prvních příznaků do finální diagnózy, jsme analyzovali záznamy od 1004 po sobě jdoucích pacientů s akutní (AL) a chronickou (CL) leukémií diagnostikovaných v letech 2004 až 2009.
Links
| MSM0021622430, plan (intention) |
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