JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ and Petr DUBOVÝ. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. Neuroscience Letters. Elsevier Ireland Ltd., 2011, vol. 501, No 2, p. 86-91. ISSN 0304-3940. Available from: https://dx.doi.org/10.1016/j.neulet.2011.06.052. |
Other formats:
BibTeX
LaTeX
RIS
@article{949872, author = {Jančálek, Radim and Hradilová Svíženská, Ivana and Klusáková, Ilona and Dubový, Petr}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.neulet.2011.06.052}, keywords = {Nerve injury; Cytokines; Neuroinflammation; Sham operation}, language = {eng}, issn = {0304-3940}, journal = {Neuroscience Letters}, title = {Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve}, volume = {501}, year = {2011} }
TY - JOUR ID - 949872 AU - Jančálek, Radim - Hradilová Svíženská, Ivana - Klusáková, Ilona - Dubový, Petr PY - 2011 TI - Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve JF - Neuroscience Letters VL - 501 IS - 2 SP - 86-91 EP - 86-91 PB - Elsevier Ireland Ltd. SN - 03043940 KW - Nerve injury KW - Cytokines KW - Neuroinflammation KW - Sham operation N2 - Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4–L5 and C7–C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG. Changes of IL-10 in nonassociated DRG could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of the DRG neurons for regenerating their axons following a conditioning lesion. ER -
JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ and Petr DUBOVÝ. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. \textit{Neuroscience Letters}. Elsevier Ireland Ltd., 2011, vol.~501, No~2, p.~86-91. ISSN~0304-3940. Available from: https://dx.doi.org/10.1016/j.neulet.2011.06.052.
|