KUBEK, Tomáš, Nabil Ahmed GHALIB a Petr DUBOVÝ. Endoneurial extracellular matrix influences regeneration and maturation of motor nerve axons—A model of acellular nerve graft. Neuroscience Letters. 2011, roč. 496, č. 2, s. 75-79. ISSN 0304-3940. doi:10.1016/j.neulet.2011.03.085.
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Základní údaje
Originální název Endoneurial extracellular matrix influences regeneration and maturation of motor nerve axons—A model of acellular nerve graft
Autoři KUBEK, Tomáš (203 Česká republika, domácí), Nabil Ahmed GHALIB (887 Jemen, domácí) a Petr DUBOVÝ (203 Česká republika, garant, domácí).
Vydání Neuroscience Letters, 2011, 0304-3940.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30000 3. Medical and Health Sciences
Stát vydavatele Irsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 2.105
Kód RIV RIV/00216224:14110/11:00053054
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.neulet.2011.03.085
UT WoS 000291196800003
Klíčová slova anglicky Acellular nerve graft; Extracellular matrix; Nerve regeneration
Příznaky Mezinárodní význam
Změnil Změnil: Mgr. Michal Petr, učo 65024. Změněno: 20. 4. 2012 15:08.
Anotace
Clinical results of functional reinnervation after application of autogeneous nerve grafts obtained from cutaneous nerves have not always been satisfactory.Aforeign extracellular condition especially for regeneration of motor axons is assumed to be one of the reasons explaining these unsuccessful results. The role of endoneurial extracellular matrix in regeneration and maturation of motor axons was studied using acellular nerve segment prepared from muscular or cutaneous nerves applied between stumps of transected motor branch of the femoral nerve. No differences were found in the numbers of regenerated axons and related motoneurons through the motor and cutaneous nerve grafts 1 month after operation. Two months from grafting, however, the numbers of motoneurons and regenerated axons were increased significantly in the motor grafts while these were decreased after regeneration through the cutaneous grafts compared with 1 month. Axons’ diameter and thickness of their myelin sheaths were similar in the cutaneous grafts 1 and 2 months after grafting. In comparison to 1 month, axons had larger diameter and thicker myelin in the motor than cutaneous nerve grafts 2 months from their application. Results of morphometric analysis indicate more beneficial extracellular conditions for regeneration and maturation of myelinated motor nerve axons in the acellular motor than cutaneous nerve graft. Generally, the results revealed that the endoneurial extracellular matrix of motor fibers has a positive effect on regeneration and maturation of motor nerve axons after lesion.
Návaznosti
MSM0021622404, záměrNázev: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
VytisknoutZobrazeno: 23. 5. 2022 03:25