KUBEK, Tomáš, Nabil Ahmed GHALIB and Petr DUBOVÝ. Endoneurial extracellular matrix influences regeneration and maturation of motor nerve axons—A model of acellular nerve graft. Neuroscience Letters. 2011, vol. 496, No 2, p. 75-79. ISSN 0304-3940. doi:10.1016/j.neulet.2011.03.085.
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Basic information
Original name Endoneurial extracellular matrix influences regeneration and maturation of motor nerve axons—A model of acellular nerve graft
Authors KUBEK, Tomáš (203 Czech Republic, belonging to the institution), Nabil Ahmed GHALIB (887 Yemen, belonging to the institution) and Petr DUBOVÝ (203 Czech Republic, guarantor, belonging to the institution).
Edition Neuroscience Letters, 2011, 0304-3940.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.105
RIV identification code RIV/00216224:14110/11:00053054
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.neulet.2011.03.085
UT WoS 000291196800003
Keywords in English Acellular nerve graft; Extracellular matrix; Nerve regeneration
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 20. 4. 2012 15:08.
Abstract
Clinical results of functional reinnervation after application of autogeneous nerve grafts obtained from cutaneous nerves have not always been satisfactory.Aforeign extracellular condition especially for regeneration of motor axons is assumed to be one of the reasons explaining these unsuccessful results. The role of endoneurial extracellular matrix in regeneration and maturation of motor axons was studied using acellular nerve segment prepared from muscular or cutaneous nerves applied between stumps of transected motor branch of the femoral nerve. No differences were found in the numbers of regenerated axons and related motoneurons through the motor and cutaneous nerve grafts 1 month after operation. Two months from grafting, however, the numbers of motoneurons and regenerated axons were increased significantly in the motor grafts while these were decreased after regeneration through the cutaneous grafts compared with 1 month. Axons’ diameter and thickness of their myelin sheaths were similar in the cutaneous grafts 1 and 2 months after grafting. In comparison to 1 month, axons had larger diameter and thicker myelin in the motor than cutaneous nerve grafts 2 months from their application. Results of morphometric analysis indicate more beneficial extracellular conditions for regeneration and maturation of myelinated motor nerve axons in the acellular motor than cutaneous nerve graft. Generally, the results revealed that the endoneurial extracellular matrix of motor fibers has a positive effect on regeneration and maturation of motor nerve axons after lesion.
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MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, Research Intents
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