DUBOVÝ, Petr, Otakar RAŠKA, Ilona KLUSÁKOVÁ, Lubomír STEJSKAL, Pavel ČELAKOVSKÝ and Pavel HANINEC. Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy. BMC Neuroscience. Biomed Central Ltd., 2011, vol. 12, No 58, p. "nestránkováno", 12 pp. ISSN 1471-2202. doi:10.1186/1471-2202-12-58.
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Basic information
Original name Ciliary neurotrophic factor promotes motor reinnervation of the musculocutaneous nerve in an experimental model of end-to-side neurorrhaphy
Authors DUBOVÝ, Petr (203 Czech Republic, guarantor, belonging to the institution), Otakar RAŠKA (203 Czech Republic), Ilona KLUSÁKOVÁ (203 Czech Republic, belonging to the institution), Lubomír STEJSKAL (203 Czech Republic), Pavel ČELAKOVSKÝ (203 Czech Republic) and Pavel HANINEC (203 Czech Republic).
Edition BMC Neuroscience, Biomed Central Ltd. 2011, 1471-2202.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.042
RIV identification code RIV/00216224:14740/11:00053056
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1186/1471-2202-12-58
UT WoS 000293476600001
Keywords in English NEURON REGENERATION ACCURACY; PERIPHERAL-NERVE; BRACHIAL-PLEXUS; SCHWANN-CELLS; ULNAR NERVE; SKELETAL-MUSCLE; SCIATIC-NERVE; FACTOR CNTF; ADULT-RAT; IGF-I
Tags ok, rivok
Tags International impact
Changed by Changed by: Olga Křížová, učo 56639. Changed: 31. 3. 2012 22:34.
Abstract
Repair nerve if proximal stump is unavailable and autogenous nerve grafts are insufficient for reconstructing extensive nerve damage is difficult. Alternative methods have been developed, including lateral anastomosis based on axons’ ability to send out collateral sprouts into denervated nerve. The aim of this study was to quantitatively assess collateral sprouts sent out by intact motor and sensory axons in the end-to-side neurorrhaphy model following intrathecal administration of CNTF in comparison with phosphate buffered saline and Cerebrolysin. The distal stump of rat transected musculocutaneous nerve was attached in an end-to-side fashion with ulnar nerve. Animals were allowed to survive for 2 months. The present experimental study confirms end-to-side neurorrhaphy as an alternative method for reconstructing severed peripheral nerves. CNTF promotes motor reinnervation of the MCN stump after its end-toside neurorrhaphy with ulnar nerve and improves functional recovery of the biceps brachii muscle.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
NS10496, research and development projectName: Vymezení úspěšnosti end-to-side anastomózy periferních nervů ve vztahu k ostatním neurotizačním technikám v klinické praxi a využití neurotrofických látek aplikovaných ve formě plasmidů v experimentálním modelu
Investor: Ministry of Health of the CR
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