Plasma HDL-cholesterol and triglyceride levels in familial
hypercholesterolemia: Data from the MedPed CZ database and the
Czech population

J 2011

Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population

SOŠKA, Vladimír, Tomáš FREIBERGER, Renata CIFKOVÁ, Věra LÁNSKÁ, Michal VRABLÍK et. al.

Basic information

Original name

Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population

Authors

SOŠKA, Vladimír (203 Czech Republic, belonging to the institution), Tomáš FREIBERGER (203 Czech Republic), Renata CIFKOVÁ (203 Czech Republic), Věra LÁNSKÁ (203 Czech Republic), Michal VRABLÍK (203 Czech Republic), Lenka FAJKUSOVÁ (203 Czech Republic) and Richard ČEŠKA (203 Czech Republic, guarantor)

Edition

Clinica Chimica Acta, 2011, 0009-8981

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.535

RIV identification code

RIV/00216224:14740/11:00053069

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.cca.2011.01.017

UT WoS

000291125200019

Keywords in English

Familial hypercholesterolemia; HDL-cholesterol; Triglycerides; Familial defective apolipoprotein B-100 (FDB); Czech post-MONICA study

Abstract

V originále

The aim of this study was to compare HDL-cholesterol and triglyceride levels in patients with familial hypercholesterolemia (FH) with a representative sample of the Czech population. For the FH group: data of 1728 adult patients with FH (600 males and 1128 females) were taken from the MedPed CR database. The control group were 1995 individuals of the population sample of the Czech post-MONICA study (956 males and 1039 females). Compared with controls, FH males showed higher levels of HDL-cholesterol and triglycerides. After adjustment for age and BMI, the increase in triglycerides remained significant in the subgroup of non-FDB males only. Compared with controls, HDL-cholesterol was lower, while triglycerides were higher in FH females. After adjustment for age and BMI, HDL-cholesterol remained lower in the subgroup of FH females without FDB whereas triglycerides were higher in both female subgroups. A lower HDL-C in the group of FH patients compared with control subjects was demonstrated in FH females without FDB only. Elevated triglyceride levels were found in FH males and females, except for males with FDB.

Links

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

2B08060, research and development project

Name: Vývoj diagnostiky a léčby závažných onemocnění srdce a cév pomocí genomických a epigenomických přístupů (Acronym: EPICARD)

Investor: Ministry of Education, Youth and Sports of the CR, Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches

Citovat

SOŠKA, Vladimír, Tomáš FREIBERGER, Renata CIFKOVÁ, Věra LÁNSKÁ, Michal VRABLÍK, Lenka FAJKUSOVÁ and Richard ČEŠKA. Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population. Clinica Chimica Acta. 2011, vol. 412, 11-12, p. 920-924. ISSN 0009-8981. Available from: https://dx.doi.org/10.1016/j.cca.2011.01.017.

@article{949952,
   author = {Soška, Vladimír and Freiberger, Tomáš and Cifková, Renata and Lánská, Věra and Vrablík, Michal and Fajkusová, Lenka and Češka, Richard},
   article_number = {11-12},
   doi = {http://dx.doi.org/10.1016/j.cca.2011.01.017},
   keywords = {Familial hypercholesterolemia; HDL-cholesterol; Triglycerides; Familial defective apolipoprotein B-100 (FDB); Czech post-MONICA study},
   language = {eng},
   issn = {0009-8981},
   journal = {Clinica Chimica Acta},
   title = {Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population},
   volume = {412},
   year = {2011}
}

TY  - JOUR
ID  - 949952
AU  - Soška, Vladimír - Freiberger, Tomáš - Cifková, Renata - Lánská, Věra - Vrablík, Michal - Fajkusová, Lenka - Češka, Richard
PY  - 2011
TI  - Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population
JF  - Clinica Chimica Acta
VL  - 412
IS  - 11-12
SP  - 920-924
EP  - 920-924
SN  - 00098981
KW  - Familial hypercholesterolemia
KW  - HDL-cholesterol
KW  - Triglycerides
KW  - Familial defective apolipoprotein B-100 (FDB)
KW  - Czech post-MONICA study
N2  - The aim of this study was to compare HDL-cholesterol and triglyceride levels in patients with familial hypercholesterolemia (FH) with a representative sample of the Czech population. For the FH group: data of 1728 adult patients with FH (600 males and 1128 females) were taken from the MedPed CR database. The control group were 1995 individuals of the population sample of the Czech post-MONICA study (956 males and 1039 females). Compared with controls, FH males showed higher levels of HDL-cholesterol and triglycerides. After adjustment for age and BMI, the increase in triglycerides remained significant in the subgroup of non-FDB males only. Compared with controls, HDL-cholesterol was lower, while triglycerides were higher in FH females. After adjustment for age and BMI, HDL-cholesterol remained lower in the subgroup of FH females without FDB whereas triglycerides were higher in both female subgroups. A lower HDL-C in the group of FH patients compared with control subjects was demonstrated in FH females without FDB only. Elevated triglyceride levels were found in FH males and females, except for males with FDB.
ER  -

SOŠKA, Vladimír, Tomáš FREIBERGER, Renata CIFKOVÁ, Věra LÁNSKÁ, Michal VRABLÍK, Lenka FAJKUSOVÁ and Richard ČEŠKA. Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population. \textit{Clinica Chimica Acta}. 2011, vol.~412, 11-12, p.~920-924. ISSN~0009-8981. Available from: https://dx.doi.org/10.1016/j.cca.2011.01.017.

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