Expression and characterization of c-Myb in prenatal
odontogenesis

J 2011

Expression and characterization of c-Myb in prenatal odontogenesis

MATALOVÁ, Eva, Marcela BUCHTOVÁ, Abigail S TUCKER, Timothy P BENDER, Eva JANEČKOVÁ et. al.

Basic information

Original name

Expression and characterization of c-Myb in prenatal odontogenesis

Name in Czech

Exprese a charakterizace c-Myb v prenatální odontogenezi

Authors

MATALOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution), Marcela BUCHTOVÁ (203 Czech Republic, belonging to the institution), Abigail S TUCKER (826 United Kingdom of Great Britain and Northern Ireland), Timothy P BENDER (840 United States of America), Eva JANEČKOVÁ (203 Czech Republic, belonging to the institution), Vlasta LUNGOVÁ (203 Czech Republic), Simona BALKOVÁ (203 Czech Republic, belonging to the institution) and Jan ŠMARDA (203 Czech Republic, belonging to the institution)

Edition

Development, Growth and Differentiation, USA, WILEY-BLACKWELL, 2011, 0012-1592

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.210

RIV identification code

RIV/00216224:14110/11:00053073

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x

UT WoS

000293902200004

Keywords in English

morphogenesis; mouse; Myb; pig; tooth

Abstract

V originále

The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c-Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c-Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c-Myb during tooth mineralization.

Links

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

Citovat

MATALOVÁ, Eva, Marcela BUCHTOVÁ, Abigail S TUCKER, Timothy P BENDER, Eva JANEČKOVÁ, Vlasta LUNGOVÁ, Simona BALKOVÁ and Jan ŠMARDA. Expression and characterization of c-Myb in prenatal odontogenesis. Development, Growth and Differentiation. USA: WILEY-BLACKWELL, 2011, vol. 53, No 6, p. 793-803. ISSN 0012-1592. Available from: https://dx.doi.org/10.1111/j.1440-169X.2011.01287.x.

@article{949958,
   author = {Matalová, Eva and Buchtová, Marcela and Tucker, Abigail S and Bender, Timothy P and Janečková, Eva and Lungová, Vlasta and Balková, Simona and Šmarda, Jan},
   article_location = {USA},
   article_number = {6},
   doi = {http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x},
   keywords = {morphogenesis; mouse; Myb; pig; tooth},
   language = {eng},
   issn = {0012-1592},
   journal = {Development, Growth and Differentiation},
   title = {Expression and characterization of c-Myb in prenatal odontogenesis},
   volume = {53},
   year = {2011}
}

TY  - JOUR
ID  - 949958
AU  - Matalová, Eva - Buchtová, Marcela - Tucker, Abigail S - Bender, Timothy P - Janečková, Eva - Lungová, Vlasta - Balková, Simona - Šmarda, Jan
PY  - 2011
TI  - Expression and characterization of c-Myb in prenatal odontogenesis
JF  - Development, Growth and Differentiation
VL  - 53
IS  - 6
SP  - 793-803
EP  - 793-803
PB  - WILEY-BLACKWELL
SN  - 00121592
KW  - morphogenesis
KW  - mouse
KW  - Myb
KW  - pig
KW  - tooth
N2  - The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c-Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c-Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c-Myb during tooth mineralization.
ER  -

MATALOVÁ, Eva, Marcela BUCHTOVÁ, Abigail S TUCKER, Timothy P BENDER, Eva JANEČKOVÁ, Vlasta LUNGOVÁ, Simona BALKOVÁ and Jan ŠMARDA. Expression and characterization of c-Myb in prenatal odontogenesis. \textit{Development, Growth and Differentiation}. USA: WILEY-BLACKWELL, 2011, vol.~53, No~6, p.~793-803. ISSN~0012-1592. Available from: https://dx.doi.org/10.1111/j.1440-169X.2011.01287.x.

Detailed Information on Publication Record