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@article{950097,
author = {Křížková, Soňa and Ryvolová, Markéta and Gumulec, Jaromír and Masařík, Michal and Adam, Vojtěch and Majzlík, Petr and Hubálek, Jaromír and Provazník, Ivo and Kizek, René},
article_number = {15},
doi = {http://dx.doi.org/10.1002/elps.201000519},
keywords = {Blood marker Glutathione Metallothionein Prostate cancer Prostatespecific antigen},
language = {eng},
issn = {0173-0835},
journal = {Electrophoresis},
title = {Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker},
volume = {32},
year = {2011}
}
TY - JOUR
ID - 950097
AU - Křížková, Soňa - Ryvolová, Markéta - Gumulec, Jaromír - Masařík, Michal - Adam, Vojtěch - Majzlík, Petr - Hubálek, Jaromír - Provazník, Ivo - Kizek, René
PY - 2011
TI - Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker
JF - Electrophoresis
VL - 32
IS - 15
SP - 1952–1961
EP - 1952–1961
SN - 01730835
KW - Blood marker Glutathione Metallothionein Prostate cancer Prostatespecific antigen
N2 - Prostate-specific antigen (PSA) is a routinely used marker of prostate cancer; however, the cut-off values for unambiguous positive/negative prostate cancer diagnoses are not defined. Therefore, despite the best effort, certain percentage of misdiagnosed cases is being recorded every year. For this reason, search formore specific diagnosticmarkers is of great interest. In this study, systematic comparison of PSA and metallothionein (MT) levels in blood serum of 46 prostate cancer-diagnosed patients is presented. It is clearly demonstrated that PSA levels vary significantly and despite normal total PSA values in the range of 0 – 4 ng/mL were obtained in over 36.9% of cases, positive prostate cancer was diagnosed by biopsy. In contrary, MT levels were considerably elevated in all tested samples and no significant variations were observed. These results are indicating the potential of MT as an additional prostate cancer marker reducing, in combination with PSA, the probability of false positive/negative diagnosis. To increase the throughput of the screening, chip-based capillary electrophoresis was suggested as a rapid and effective method for the fingerprinting analysis of prostate cancer from diseased blood sera.
ER -
KŘÍŽKOVÁ, Soňa, Markéta RYVOLOVÁ, Jaromír GUMULEC, Michal MASAŘÍK, Vojtěch ADAM, Petr MAJZLÍK, Jaromír HUBÁLEK, Ivo PROVAZNÍK and René KIZEK. Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarker. \textit{Electrophoresis}. 2011, vol.~32, No~15, p.~1952–1961. ISSN~0173-0835. Available from: https://dx.doi.org/10.1002/elps.201000519.
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