Other formats:
BibTeX
LaTeX
RIS
@proceedings{950796, author = {Vařecha, Miroslav and Potěšilová, Michaela and Matula, Pavel and Kozubek, Michal}, booktitle = {19th Euroconference on Apoptosis - Metabolism, Epigenetics and Death}, keywords = {endonuclease G; histone 2B; DNA topoisomerase; apoptosis-inducing factor; microscopy of living cells; FRET.}, language = {eng}, title = {Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells}, url = {http://www.dmbr.ugent.be/ext/public/ecdo/2011/index.php}, year = {2011} }
TY - CONF ID - 950796 AU - Vařecha, Miroslav - Potěšilová, Michaela - Matula, Pavel - Kozubek, Michal PY - 2011 TI - Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells KW - endonuclease G KW - histone 2B KW - DNA topoisomerase KW - apoptosis-inducing factor KW - microscopy of living cells KW - FRET. UR - http://www.dmbr.ugent.be/ext/public/ecdo/2011/index.php N2 - Apoptosis is a natural form of cell death involved in many physiological changes in the cell. During some forms of cell death, proteins endonuclease G (EndoG) and apoptosis-inducing factor (AIF) are released from mitochondria and then they translocate into the cell nuclei, where they participate in chromatin degradation in a caspase-independent way. The C. elegans homolog of AIF was shown to induce apoptosis and to interact with a homolog of EndoG and together they mediated chromatin DNA degradation. Our results show that EndoG interacts with histone H2B, AIF, and DNA topoisomerase II alpha (TOPO2a). Also AIF was found to interact with TOPO2a. Therefore we can conclude that EndoG, AIF, and TOPO2a may form a protein complex allowing chromatin degradation in apoptotic nucleus. These results offer an important insight into the mechanism of apoptotic cell death, which plays a major role in development and progression of degenerative diseases, cancer, and inflammation. ER -
VAŘECHA, Miroslav, Michaela POTĚŠILOVÁ, Pavel MATULA and Michal KOZUBEK. Endonuclease G interacts with histone H2B, AIF, and DNA topoisomerase II alpha during apoptosis as revealed by FRET analysis of living cells. In \textit{19th Euroconference on Apoptosis - Metabolism, Epigenetics and Death}. 2011.
|