The Neural Substrate of Predictive Motor Timing in
Spinocerebellar Ataxia

J 2011

The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia

BAREŠ, Martin, Ovidiu V. LUNGU, Tao LIU, Tobias WAECHTER, Christopher M. GOMEZ et. al.

Basic information

Original name

The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia

Authors

BAREŠ, Martin (203 Czech Republic, guarantor, belonging to the institution), Ovidiu V. LUNGU (840 United States of America), Tao LIU (840 United States of America), Tobias WAECHTER (840 United States of America), Christopher M. GOMEZ (840 United States of America) and James ASHE (840 United States of America)

Edition

Cerebellum, 2011, 1473-4222

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.207

RIV identification code

RIV/00216224:14110/11:00053159

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12311-010-0237-y

UT WoS

000291601100008

Keywords in English

Cerebellum; Basal ganglia; Motor timing; Functional imaging

Abstract

V originále

The neural mechanisms involved in motor timing are subcortical, involving mainly cerebellum and basal ganglia. However, the role played by these structures in predictive motor timing is not well understood. Unlike motor timing, which is often tested using rhythm production tasks, predictive motor timing requires visuo-motor coordination in anticipation of a future event, and it is evident in behaviors such as catching a ball or shooting a moving target. We examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. The performance of the healthy subjects was better than that of the spinocerebellar ataxia. Successful performance in both groups was associated with increased activity in the cerebellum (right dentate nucleus, left uvula (lobule V), and lobule VI), thalamus, and in several cortical areas. The superior performance in the controls was related to activation in thalamus, putamen (lentiform nucleus) and cerebellum (right dentate nucleus and culmen-lobule IV), which were not activated either in the spinocerebellar subjects or within a subgroup of controls who performed poorly. Both the cerebellum and the basal ganglia are necessary for the predictive motor timing. The degeneration of the cerebellum associated with spinocerebellar types 6 and 8 appears to lead to quantitative rather than qualitative deficits in temporal processing. The lack of any areas with greater activity in the spinocerebellar group than in controls suggests that limited functional reorganization occurs in this condition.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

BAREŠ, Martin, Ovidiu V. LUNGU, Tao LIU, Tobias WAECHTER, Christopher M. GOMEZ and James ASHE. The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia. Cerebellum. 2011, vol. 10, No 2, p. 233-244. ISSN 1473-4222. Available from: https://dx.doi.org/10.1007/s12311-010-0237-y.

@article{950806,
   author = {Bareš, Martin and Lungu, Ovidiu V. and Liu, Tao and Waechter, Tobias and Gomez, Christopher M. and Ashe, James},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s12311-010-0237-y},
   keywords = {Cerebellum; Basal ganglia; Motor timing; Functional imaging},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia},
   volume = {10},
   year = {2011}
}

TY  - JOUR
ID  - 950806
AU  - Bareš, Martin - Lungu, Ovidiu V. - Liu, Tao - Waechter, Tobias - Gomez, Christopher M. - Ashe, James
PY  - 2011
TI  - The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia
JF  - Cerebellum
VL  - 10
IS  - 2
SP  - 233-244
EP  - 233-244
SN  - 14734222
KW  - Cerebellum
KW  - Basal ganglia
KW  - Motor timing
KW  - Functional imaging
N2  - The neural mechanisms involved in motor timing are subcortical, involving mainly cerebellum and basal ganglia. However, the role played by these structures in predictive motor timing is not well understood. Unlike motor timing, which is often tested using rhythm production tasks, predictive motor timing requires visuo-motor coordination in anticipation of a future event, and it is evident in behaviors such as catching a ball or shooting a moving target. We examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. The performance of the healthy subjects was better than that of the spinocerebellar ataxia. Successful performance in both groups was associated with increased activity in the cerebellum (right dentate nucleus, left uvula (lobule V), and lobule VI), thalamus, and in several cortical areas. The superior performance in the controls was related to activation in thalamus, putamen (lentiform nucleus) and cerebellum (right dentate nucleus and culmen-lobule IV), which were not activated either in the spinocerebellar subjects or within a subgroup of controls who performed poorly. Both the cerebellum and the basal ganglia are necessary for the predictive motor timing. The degeneration of the cerebellum associated with spinocerebellar types 6 and 8 appears to lead to quantitative rather than qualitative deficits in temporal processing. The lack of any areas with greater activity in the spinocerebellar group than in controls suggests that limited functional reorganization occurs in this condition.
ER  -

BAREŠ, Martin, Ovidiu V. LUNGU, Tao LIU, Tobias WAECHTER, Christopher M. GOMEZ and James ASHE. The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia. \textit{Cerebellum}. 2011, vol.~10, No~2, p.~233-244. ISSN~1473-4222. Available from: https://dx.doi.org/10.1007/s12311-010-0237-y.

Detailed Information on Publication Record