Involvement of the subthalamic nucleus in cognitive functions —
A concept

J 2011

Involvement of the subthalamic nucleus in cognitive functions — A concept

BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ and Ivan REKTOR

Basic information

Original name

Involvement of the subthalamic nucleus in cognitive functions — A concept

Authors

BALÁŽ, Marek (703 Slovakia, guarantor, belonging to the institution), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution)

Edition

Journal of the Neurological Sciences, 2011, 0022-510X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.353

RIV identification code

RIV/00216224:14110/11:00053200

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jns.2011.07.016

UT WoS

000296927500024

Keywords in English

Subthalamic nucleus; Basal ganglia; Cognitive functions; Deep brain stimulation; Hyperdirect pathway

Abstract

V originále

The involvement of the subthalamic nucleus (STN) in a broad spectrum of various non-motor functions – attention, executive functions, verbal learning and memory, verbal abstract reasoning, conflict resolution, and emotions – has been reported. The STN has an anatomically central position within the basal ganglia(BG)-thalamocortical motor, associative and limbic circuits. The STN might interfere with non-motor functions as an indirect modulator rather than a regulator. Mechanisms modulating the motor and non-motor functions might differ. The STN has been implicated in control of non-motor behaviors via the tuning of specific circuits depending on the task. The STN might modulate selected non-motor functions via contextual modulation of certain cortical areas. Based on intracerebral recordings, we proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. These findings support the hypothesis of a cortico-STN bypass of the BG-thalamocortical circuitry under some circumstances. The exact role of the STN and the BG in non-motor functions remains an important and interesting challenge for future research.

Citovat

BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ and Ivan REKTOR. Involvement of the subthalamic nucleus in cognitive functions — A concept. Journal of the Neurological Sciences. 2011, vol. 310, 1-2, p. 96-99. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.07.016.

@article{950971,
   author = {Baláž, Marek and Bočková, Martina and Rektorová, Irena and Rektor, Ivan},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2011.07.016},
   keywords = {Subthalamic nucleus; Basal ganglia; Cognitive functions; Deep brain stimulation; Hyperdirect pathway},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the Neurological Sciences},
   note = {7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders, Barcelona, DEC 09-12, 2010},
   title = {Involvement of the subthalamic nucleus in cognitive functions — A concept},
   volume = {310},
   year = {2011}
}

TY  - JOUR
ID  - 950971
AU  - Baláž, Marek - Bočková, Martina - Rektorová, Irena - Rektor, Ivan
PY  - 2011
TI  - Involvement of the subthalamic nucleus in cognitive functions — A concept
JF  - Journal of the Neurological Sciences
VL  - 310
IS  - 1-2
SP  - 96-99
EP  - 96-99
SN  - 0022510X
N1  - 7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders, Barcelona, DEC 09-12, 2010
KW  - Subthalamic nucleus
KW  - Basal ganglia
KW  - Cognitive functions
KW  - Deep brain stimulation
KW  - Hyperdirect pathway
N2  - The involvement of the subthalamic nucleus (STN) in a broad spectrum of various non-motor functions – attention, executive functions, verbal learning and memory, verbal abstract reasoning, conflict resolution, and emotions – has been reported. The STN has an anatomically central position within the basal ganglia(BG)-thalamocortical motor, associative and limbic circuits. The STN might interfere with non-motor functions as an indirect modulator rather than a regulator. Mechanisms modulating the motor and non-motor functions might differ. The STN has been implicated in control of non-motor behaviors via the tuning of specific circuits depending on the task. The STN might modulate selected non-motor functions via contextual modulation of certain cortical areas. Based on intracerebral recordings, we proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. These findings support the hypothesis of a cortico-STN bypass of the BG-thalamocortical circuitry under some circumstances. The exact role of the STN and the BG in non-motor functions remains an important and interesting challenge for future research.
ER  -

BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ and Ivan REKTOR. Involvement of the subthalamic nucleus in cognitive functions — A concept. \textit{Journal of the Neurological Sciences}. 2011, vol.~310, 1-2, p.~96-99. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.07.016.

Detailed Information on Publication Record