PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra, Miloslava FOJTOVÁ, Petr MOKROŠ, Klaus D. GRASSER and Jiří FAJKUS. Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana. CURRENT PROTEIN & PEPTIDE SCIENCE. BENTHAM SCIENCE PUBL LTD, 2011, vol. 12, No 2, p. 105-111. ISSN 1389-2037.
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Basic information
Original name Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana
Authors PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra (203 Czech Republic, belonging to the institution), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Petr MOKROŠ (203 Czech Republic, belonging to the institution), Klaus D. GRASSER (276 Germany) and Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution).
Edition CURRENT PROTEIN & PEPTIDE SCIENCE, BENTHAM SCIENCE PUBL LTD, 2011, 1389-2037.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Arab Emirates
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.886
RIV identification code RIV/00216224:14740/11:00050006
Organization unit Central European Institute of Technology
UT WoS 000291109700005
Keywords in English TRANSCRIPTION FACTOR DOF2; MOBILITY GROUP PROTEINS; DNA-BINDING; MAMMALIAN TELOMERES; METHYLATION; HETEROCHROMATIN; RNA; PLANTS; STRESS; REPAIR
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Špillingová, učo 110713. Changed: 14/6/2016 11:01.
Abstract
HMGB proteins play important role in dynamic changes of chromatin structure. Here, we summarise the roles of plant HMGB proteins in regulation of chromatin structure and dynamics and report on the newly identified role of AtHMGB1 protein in the regulation of plant telomere length. Astonishingly, contrary to mice mHMGB1 homologue, AtHMGB1 does not affect telomerase activity and AtHMGB1 loss or overexpression does not cause any obvious changes in chromatin architecture.
Abstract (in Czech)
HMGB proteiny hrají důležitou roli v dynamických změnách chromatinové struktury. Zde shrnujeme roli rostlinných HMGB proteinů v regulaci chromatinové struktury a dynamiky a nově idetifikuje roli AtHMGB1 proteinu v regulaci délky rostlinných telomer. Překvapivě na rozdíl od proteinu mHMGB1, který je myším homologem, AtHMGB1 neovlivňuje aktivitu telomerázy a ztráta či overexprese AtHMGB1 nezpůsobuje žádné významné změny v architektuře chromatinu.
Links
GA204/08/1530, research and development projectName: Objasnění úlohy proteinu HMGB1 v udržování genomové stability
Investor: Czech Science Foundation, Understanding of HMGB1 protein involvement in maintaining genome stability
GP521/08/P452, research and development projectName: Charakterizace a funkční diverzita proteinů rodiny SMH, která je specifická pro rostliny
Investor: Czech Science Foundation, Characterisation of functional diversity of the plant-specific SMH family of proteins
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
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