RUSZOVÁ, Ema a Lukáš KUBALA. Potential anti-aging properties of a hydroglycolic preparation from Epilobium angustifolium preparation from aerial parts. 2011.
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Základní údaje
Originální název Potential anti-aging properties of a hydroglycolic preparation from Epilobium angustifolium preparation from aerial parts
Autoři RUSZOVÁ, Ema a Lukáš KUBALA.
Vydání 2011.
Další údaje
Typ výsledku Prezentace na konferencích
Utajení není předmětem státního či obchodního tajemství
WWW URL
Organizační jednotka Přírodovědecká fakulta
Klíčová slova česky Epilobium angustifolium, senescence, UV záření, metaloproteináza, hyaluronidáza
Klíčová slova anglicky Epilobium angustifolim, senescence, UV exposure, metalloproteinase, hyaluronidase
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Ema Ruszová, Ph.D., učo 204560. Změněno: 3. 10. 2011 13:05.
Anotace
The potential anti-aging properties of a hydroglycolic preparation (HP) from Epilobium angustifolium were assessed by determining its ability to reduce the stress induced senescence of dermal fibroblasts (NHDF) in vitro and to protect skin against harmful UV in vivo. The chemical profile of HP was determined by using LC-DAD-MS. Treatment of NHDF by HP at 10 ug/ml increased the cell viability of senescent (serum-free cultivated cells) NHDF. This preparation diminished the connective tissue growth factor and fibronectin gene expression in senescent NHDF. It also elevated collagen release in repeatedly UV-irradiated NHDF and down-regulated the induced release of both matrix metalloproteinases (MMPs) -1 and -3, and tissue inhibitor of MMP -1 and -2. In addition, a downregulating effect of HP on gene expression of hyaluronidase 2 in repeatedly UV-irradiated NHDF was observed. The in vivo experiments showed that the application of HP before single UV-exposure protected skin against UVinduced erythema formation. Major constituents of HP were preliminarily identified as gallic acid, oenothein B, chlorogenic acid, myricetin-3-O-hexoside, myricetin-3-O-rhamnoside, quercetin-7-O-glucuronide and kaempferol- 3-O-hexoside. The observed reduction in connective tissue growth factor, fibronectin and tissue inhibitor of MMPs indicates the antifibrotic and anti-scarring potential of HP. It is suggested that this phytopreparation protects dermal cells and extracellular matrix components against cutaneous aging and exhibits a significant photoprotective effect. Polyphenols, the major constituents of HP, may account for the observed benefits. HP from Epilobium angustifolium could be a potential candidate to be used as an active ingredient in dermatological and cosmetic formulations.
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Barcelona_-_2__v1__olzpjxks.pdf  Ruszová, E. 3. 10. 2011

Práva

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Právo vkládat
 
Právo spravovat
  • osoba Mgr. Ema Ruszová, Ph.D., učo 204560
  • osoba doc. Mgr. Lukáš Kubala, Ph.D., učo 7056
Atributy
 
Barcelona_-_2__v1_.pdf Licence Creative Commons  Verze souboru Ruszová, E. 3. 10. 2011

Práva

Právo číst
 
Právo vkládat
 
Právo spravovat
  • osoba Mgr. Ema Ruszová, Ph.D., učo 204560
  • osoba doc. Mgr. Lukáš Kubala, Ph.D., učo 7056
Atributy
 
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Požádat autora o autorský výtisk Zobrazeno: 24. 7. 2021 07:52