DOSTÁLEK, Miroslav, Jana PISTOVČÁKOVÁ, Jan JUŘICA, Alexandra ŠULCOVÁ and Josef TOMANDL. The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic. 2011, vol. 155, No 3, p. 253-257. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2011.047. |
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@article{952508, author = {Dostálek, Miroslav and Pistovčáková, Jana and Juřica, Jan and Šulcová, Alexandra and Tomandl, Josef}, article_number = {3}, doi = {http://dx.doi.org/10.5507/bp.2011.047}, keywords = {St John‘s wort; Hypericum perforatum; Cytochrome P450; Liver isolated perfused; Rat}, language = {eng}, issn = {1213-8118}, journal = {Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic}, title = {The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver}, url = {http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf}, volume = {155}, year = {2011} }
TY - JOUR ID - 952508 AU - Dostálek, Miroslav - Pistovčáková, Jana - Juřica, Jan - Šulcová, Alexandra - Tomandl, Josef PY - 2011 TI - The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver JF - Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic VL - 155 IS - 3 SP - 253-257 EP - 253-257 SN - 12138118 KW - St John‘s wort KW - Hypericum perforatum KW - Cytochrome P450 KW - Liver isolated perfused KW - Rat UR - http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf L2 - http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf N2 - We previously reported the effect of St John’s wort (Hypericum perforatum) standardised extract LI 160 on the activities of cytochrome P450 2C6, 2D2 and 3As (Dostalek et al., Life Sciences 2005;78(3):239-44). In this study, we aimed to assess the effect of St John’s wort on the activity of cytochrome P450 1A2. The isolated perfused rat liver model was used in our experiments with phenacetin as a marker substrate for cytochrome P450 1A2. The rate of formation of acetaminophen was significantly inhibited by the use of St John’s wort. In addition, St John‘s wort extract inhibited cytochrome P450 1A2 activity significantly more than the control inhibitor. St John’s wort significantly inhibited cytochrome P450 1A2 enzyme activity. It remains to be determined whether the co-administration of St John‘s wort extract and other medications or substrates for cytochrome P450 1A2 could result in significant drug interactions. ER -
DOSTÁLEK, Miroslav, Jana PISTOVČÁKOVÁ, Jan JUŘICA, Alexandra ŠULCOVÁ and Josef TOMANDL. The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver. \textit{Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic}. 2011, vol.~155, No~3, p.~253-257. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2011.047.
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