Aspergillus fumigatus lectin – a new procedure for studying
highly complex	interactions of multivalent lectins with their
ligands

a 2011

Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands

KOMÁREK, Jan, Josef HOUSER, Nikola KOSTLÁNOVÁ, Marie POKORNÁ, Anne IMBERTY et. al.

Basic information

Original name

Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands

Authors

KOMÁREK, Jan (203 Czech Republic, belonging to the institution), Josef HOUSER (203 Czech Republic, belonging to the institution), Nikola KOSTLÁNOVÁ (203 Czech Republic, belonging to the institution), Marie POKORNÁ (203 Czech Republic, belonging to the institution), Anne IMBERTY (250 France) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

YoungChem 2011, 2011

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10600 1.6 Biological sciences

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/11:00050064

Organization unit

Faculty of Science

ISBN

978-83-61037-28-6

Keywords (in Czech)

lektiny; Aspergillus fumigatus

Keywords in English

lectins; Aspergillus fumigatus

Abstract

V originále

Lectins are proteins or glycoproteins of non-immune origin which recognize and bind reversibly to diverse sugar structures. They are involved in recognition events in a variety of physiological and pathological processes. One of the most interesting biological function of these sugar-specific proteins is their involvement in host-pathogen interactions. Wide range of pathogenic bacteria and viruses use their surface lectins (called adhesins) for recognition and adhesion to host tissues – in the the crucial step for initiation of infection. Inhibition of these lectins by suitable carbohydrates or their analogs might prevent attachment of pathogens to host cells and prevent the disease outbreak. Aspergillus fumigatus is an ubiquitous saprophytic mold and opportunistic pathogen responsible for severe infections in immuno-compromised individuals. The project is focused on a detailed characterization of L-fucose specific lectin AFL from A. fumigatus.

Links

GA303/09/1168, research and development project

Name: Lektiny z lidských patogenů - struktura, funkce, inženýrství

Investor: Czech Science Foundation, Lectins from human pathogens - structure, function, engineering

MSM0021622413, plan (intention)

Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment

Citovat

KOMÁREK, Jan, Josef HOUSER, Nikola KOSTLÁNOVÁ, Marie POKORNÁ, Anne IMBERTY and Michaela WIMMEROVÁ. Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands (Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands.). In YoungChem 2011. 2011. ISBN 978-83-61037-28-6.

@proceedings{953482,
   author = {Komárek, Jan and Houser, Josef and Kostlánová, Nikola and Pokorná, Marie and Imberty, Anne and Wimmerová, Michaela},
   booktitle = {YoungChem 2011},
   keywords = {lectins; Aspergillus fumigatus},
   language = {eng},
   isbn = {978-83-61037-28-6},
   title = {Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands},
   year = {2011}
}

TY  - CONF
ID  - 953482
AU  - Komárek, Jan - Houser, Josef - Kostlánová, Nikola - Pokorná, Marie - Imberty, Anne - Wimmerová, Michaela
PY  - 2011
TI  - Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands
SN  - 9788361037286
KW  - lectins
KW  - Aspergillus fumigatus
N2  - Lectins are proteins or glycoproteins of non-immune origin which recognize and bind reversibly to diverse sugar structures. They are involved in recognition events in a variety of physiological and pathological processes. One of the most interesting biological function of these sugar-specific proteins is their involvement in host-pathogen interactions. Wide range of pathogenic bacteria and viruses use their surface lectins (called adhesins) for recognition and adhesion to host tissues – in the the crucial step for initiation of infection. Inhibition of these lectins by suitable carbohydrates or their analogs might prevent attachment of pathogens to host cells and prevent the disease outbreak. Aspergillus fumigatus is an ubiquitous saprophytic mold and opportunistic pathogen responsible for severe infections in immuno-compromised individuals. The project is focused on a detailed characterization of L-fucose specific lectin AFL from A. fumigatus.
ER  -

Detailed Information on Publication Record