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@proceedings{953968,
author = {Závodná, Eva and Honzíková, Nataša and Nováková, Zuzana and Hrstková, Hana and Bothová, Pavla and Brázdová, Ludmila and Fišer, Bohumil},
booktitle = {21st European Meeting on Hypertension and Cardiovascular Prevention},
keywords = {blood pressure variability; pulse interval variability;children; diabetes mellitus type 1},
language = {eng},
title = {CHANGES IN SYSTOLIC BLOOD PRESSURE AND PULSE INTERVAL VARIABILITY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS},
year = {2011}
}
TY - CONF
ID - 953968
AU - Závodná, Eva - Honzíková, Nataša - Nováková, Zuzana - Hrstková, Hana - Bothová, Pavla - Brázdová, Ludmila - Fišer, Bohumil
PY - 2011
TI - CHANGES IN SYSTOLIC BLOOD PRESSURE AND PULSE INTERVAL VARIABILITY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS
KW - blood pressure variability
KW - pulse interval variability;children
KW - diabetes mellitus type 1
N2 - Introduction: Polyneuropathy quite often accompanies diabetes mellitus and probably affects all organs. The aim of the study was to show differences in systolic blood pressure and heart rate variability in children with type 1 diabetes mellitus (T1DM). Methods: We examined 382 healthy (Co) children and adolescents (14.8 +- 2.6 years) and 34 patients with T1DM (15.0+- 3.2 years). We recorded systolic blood pressure (SBP) and pulse intervals (PI) beat-to-beat by non-invasive methods (Finapres) in all subjects for 5 min. The breathing was controlled by a metronome at a frequency of 0.33 Hz. The SBP and PI variability were determined as spectral power in the low frequency (LF) range (nSBPlf, nPIlf) and of respiratory (HF) range (nSBPhf, nPIhf) in normalised units, and in absolute values as well (vSBPlf, vPIlf, vSBPhf, vPIhf). Results: We did not find significant differences between controls and T1DM in SBP and PI variability LF range (nPIlf: Co=0.057 +- 0.031, T1DM=0.063 +- 0.027; nSBPlf: Co=0.046 +- 0.026, T1DM=0.046 +- 0.021; vPIlf: Co=15132 +- 14167, T1DM=16672 +- 16583 ms2/Hz; vSBPlf: Co=147 +- 119, T1DM=224 +- 242 mmHg2/Hz). However, there were significant differences in the HF range (nPIhf: Co=0.104 +- 0.064, T1DM=0.081 +- 0.056, p<0.05; nSBPhf: Co=0.058 +- 0.048, T1DM=0.035+-0.038, p<0.001; vPIhf: Co=30570+-39385, T1DM=17078+-16653 ms2/Hz, p<0.01; vSBPhf: Co=152+-145, T1DM=98+-63 mmHg2/Hz, p<0.05). Discussion: Decreased values of SBP and PI variability in children with T1DM in the high frequency region indicate early impairment of parasympathetic activity.
ER -
ZÁVODNÁ, Eva, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Hana HRSTKOVÁ, Pavla BOTHOVÁ, Ludmila BRÁZDOVÁ and Bohumil FIŠER. CHANGES IN SYSTOLIC BLOOD PRESSURE AND PULSE INTERVAL VARIABILITY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS. In \textit{21st European Meeting on Hypertension and Cardiovascular Prevention}. 2011. ISSN~0263-6352.
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