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@article{954192,
author = {Rázga, Filip and Ráčil, Zdeněk and Machová Poláková, Kateřina and Burešová, Lucie and Klamova, Hana and Žáčková, Daniela and Dvořáková, Dana and Polívková, Václava and Cetkovský, Petr and Mayer, Jiří},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s12185-011-0924-6},
keywords = {human organic cation transporter; ABCB1; chronic myelogenous leukemia},
language = {eng},
issn = {0925-5710},
journal = {International Journal of Hematology},
title = {The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia},
volume = {94},
year = {2011}
}
TY - JOUR
ID - 954192
AU - Rázga, Filip - Ráčil, Zdeněk - Machová Poláková, Kateřina - Burešová, Lucie - Klamova, Hana - Žáčková, Daniela - Dvořáková, Dana - Polívková, Václava - Cetkovský, Petr - Mayer, Jiří
PY - 2011
TI - The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia
JF - International Journal of Hematology
VL - 94
IS - 3
SP - 303-306
EP - 303-306
SN - 09255710
KW - human organic cation transporter
KW - ABCB1
KW - chronic myelogenous leukemia
N2 - In this study, we investigated the predictive value of pretreatment mRNA expression levels of hOCT-1 and ABCB1 in different cell populations with regard to the response to therapy at 6 and 12 months of IMA therapy. Expression levels were assessed in peripheral blood (PB) leukocytes (LEU, n = 30), polymorphonuclear cells (PMNC, n = 23), and mononuclear cells (MNC, n = 21) of PB LEU obtained from 30 patients with de novo chronic myelogenous leukemia (CML). Moreover, the available bone marrow cells (BM) were also included and analyzed (BM, n = 11). The PB and BM samples were obtained, processed, and analyzed as previously described. Responses to therapy were classified according the European LeukemiaNet 2009 (ELN) criteria: responders show an optimal response at 6 months and 12 months, while non-responders reflect a suboptimal response or therapy failure. The assessed pretreatment expression levels were stratified into two groups according to the median-a low-mRNA expression group below the median and a high-mRNA expression group equal to or above the median. The statistical evaluation of the data obtained was performed using the Fisher’s exact tests and summarized in Table 2.
ER -
RÁZGA, Filip, Zdeněk RÁČIL, Kateřina MACHOVÁ POLÁKOVÁ, Lucie BUREŠOVÁ, Hana KLAMOVA, Daniela ŽÁČKOVÁ, Dana DVOŘÁKOVÁ, Václava POLÍVKOVÁ, Petr CETKOVSKÝ and Jiří MAYER. The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia. \textit{International Journal of Hematology}. 2011, vol.~94, No~3, p.~303-306. ISSN~0925-5710. Available from: https://dx.doi.org/10.1007/s12185-011-0924-6.
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