Cisplatin utilized in sonodynamic therapy

BERNARD, Vladan and Vojtěch MORNSTEIN. Cisplatin utilized in sonodynamic therapy. In Proceedings-Biopolymers: structure and dynamics , A biophysical workshop. 2011. ISBN 978-80-263-0050-2.

Basic information

• Original name: Cisplatin utilized in sonodynamic therapy
• Name in Czech: Využití cisplatiny v sonodynamické terapii
• Authors: BERNARD, Vladan and Vojtěch MORNSTEIN.
• Edition: Proceedings-Biopolymers: structure and dynamics , A biophysical workshop, 2011.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10610 Biophysics
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Medicine
• ISBN: 978-80-263-0050-2
• Keywords (in Czech): cisplatin, sonodynamic therapy, ultrasound
• Keywords in English: cisplatina, sonodynamická terapie, ultrazvuk

Abstract

Our research was aimed to evaluate viability of human tumor cells (line A375, A2780) after combined cisplatin and far field therapeutical ultrasound treatment in vitro. The principal objective of the research was to establish the possibility of strengthening of biology effect of used platinum drug. Usage of ultrasound field, in association with sonodynamic therapy, prospectively gives an advantage in reducing the doses of cytostatic drug and/or (due to quite precisely targeting the ultrasound beam) to intensify the effect of the cytostatic drug only in the malignancy.