J 2011

Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia

BARTEČEK, Richard, Tomáš KAŠPÁREK and Eva ČEŠKOVÁ

Basic information

Original name

Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia

Name in Czech

Zmínění nežádoucích účinků antipsychotické medikace u pacientů s první epizodou schizofrenie

Authors

BARTEČEK, Richard (203 Czech Republic, guarantor, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Central European Journal of Medicine, Warsaw (Poland), Versita, 2011, 1895-1058

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.312

RIV identification code

RIV/00216224:14110/11:00053792

Organization unit

Faculty of Medicine

DOI

UT WoS

000293708800022

Keywords (in Czech)

schizofrenie; antipsychotika; zmírnění nežádoucích účinků

Keywords in English

schizophrenia; antipsychotics; withdrawal related adverse effects

Tags

International impact
Změněno: 2/2/2012 16:12, Mgr. Michal Petr

Abstract

V originále

Withdrawal-emergent adverse effects of antipsychotics are an infrequently identified condition which can appear during antipsychotic dose reduction and medication change. In this paper, we present the case of severe extrapyramidal symptoms after a dose reduction of risperidone is presented. A patient, 23 years of age, was admitted to a health care facility due to an unexpected change in his behavior, with paranoid delusions, incoherent thinking, and significant anxiety. An initial risperidone treatment was soon changed to zuclopenhixol. Subsequently, severe extrapyramidal symptoms appeared, after which the medication was switched back to resperidone. Following this treatment, the patient left the health care facility and stopped the medication of his own volition. Psychotic symptoms and massive extrapyramidal symptoms again occurred. These symptoms subsided only slowly during a subsequent treatment with olanzapine. The development of adverse neurological effects together with a worsening of productive psychotic symptomatology may be explained by withdrawal of antipsychotic medication. These symptoms are often attributed to new medications, which are prematurely discontinued after the appearance of an adverse effect, but which are potentially beneficial to a patient, provided that enough time for a spontaneous subsidence of withdrawal-emergent effects is given. Any change in antipsychotic treatment should be carefully considered and thoroughly planned.