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@article{956232,
author = {Barteček, Richard and Kašpárek, Tomáš and Češková, Eva},
article_location = {Warsaw (Poland)},
article_number = {5},
doi = {http://dx.doi.org/10.2478/s11536-011-0055-8},
keywords = {schizophrenia; antipsychotics; withdrawal related adverse effects},
language = {eng},
issn = {1895-1058},
journal = {Central European Journal of Medicine},
title = {Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia},
volume = {6},
year = {2011}
}
TY - JOUR
ID - 956232
AU - Barteček, Richard - Kašpárek, Tomáš - Češková, Eva
PY - 2011
TI - Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia
JF - Central European Journal of Medicine
VL - 6
IS - 5
SP - 662-664
EP - 662-664
PB - Versita
SN - 18951058
KW - schizophrenia
KW - antipsychotics
KW - withdrawal related adverse effects
N2 - Withdrawal-emergent adverse effects of antipsychotics are an infrequently identified condition which can appear during antipsychotic dose reduction and medication change. In this paper, we present the case of severe extrapyramidal symptoms after a dose reduction of risperidone is presented. A patient, 23 years of age, was admitted to a health care facility due to an unexpected change in his behavior, with paranoid delusions, incoherent thinking, and significant anxiety. An initial risperidone treatment was soon changed to zuclopenhixol. Subsequently, severe extrapyramidal symptoms appeared, after which the medication was switched back to resperidone. Following this treatment, the patient left the health care facility and stopped the medication of his own volition. Psychotic symptoms and massive extrapyramidal symptoms again occurred. These symptoms subsided only slowly during a subsequent treatment with olanzapine. The development of adverse neurological effects together with a worsening of productive psychotic symptomatology may be explained by withdrawal of antipsychotic medication. These symptoms are often attributed to new medications, which are prematurely discontinued after the appearance of an adverse effect, but which are potentially beneficial to a patient, provided that enough time for a spontaneous subsidence of withdrawal-emergent effects is given. Any change in antipsychotic treatment should be carefully considered and thoroughly planned.
ER -
BARTEČEK, Richard, Tomáš KAŠPÁREK and Eva ČEŠKOVÁ. Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia. \textit{Central European Journal of Medicine}. Warsaw (Poland): Versita, 2011, vol.~6, No~5, p.~662-664. ISSN~1895-1058. Available from: https://dx.doi.org/10.2478/s11536-011-0055-8.
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