Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis

HORÁK, Jakub, Lubomír JANDA, Blanka PEKÁROVÁ and Jan HEJÁTKO. Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis. CURRENT PROTEIN & PEPTIDE SCIENCE. Bentham Science Publishers, 2011, vol. 12, No 2, p. 126-136. ISSN 1389-2037.

Basic information

Original name

Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis

Authors

HORÁK, Jakub (203 Czech Republic, belonging to the institution), Lubomír JANDA (203 Czech Republic, belonging to the institution), Blanka PEKÁROVÁ (203 Czech Republic, belonging to the institution) and Jan HEJÁTKO (203 Czech Republic, guarantor, belonging to the institution)

Edition

CURRENT PROTEIN & PEPTIDE SCIENCE, Bentham Science Publishers, 2011, 1389-2037

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Arab Emirates

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.886

RIV identification code

RIV/00216224:14740/11:00050115

Organization unit

Central European Institute of Technology

UT WoS

000291109700007

Keywords in English

Arabidopsis thaliana; cytokinin; phosphorelay; plant hormone; signal integration; signal specificity; signalling pathway; two-component system

Tags

ok, rivok

Tags

International impact

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Abstract

V originále

Multistep phosphorelay (MSP) pathways mediate a wide spectrum of adaptive responses in plants, including hormonal and abiotic stress regulations. Recent genetic evidence suggests both partial redundancy and possible functional cross-talk on the one hand and a certain level of specificity on the other. Here, we discuss recent achievements improving our understanding of possible molecular mechanisms of specificity in MSP. We consider a certain evolutionary conservation of ancestral two-component signalling systems from bacteria in a process of molecular recognition that, as we have recently shown, could be applied also to a certain extent in the case of plant MSP. Furthermore, we discuss possible roles of kinase and phosphatase activities, kinetics of both these enzymatic reactions, and phosphorylation lifetime. We include also recent findings on the expression specificity of individual members of MSP pathways and, finally, based on our recent findings, we speculate about a possible role of magnesium in regulation of MSP pathways in plants. All these mechanisms could significantly influence specificity and signalling output of the MSP pathways.

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Links

ED1.1.00/02.0068, research and development project	Name: CEITEC - central european institute of technology
GAP305/11/0756, research and development project	Name: Strukturní princip specificity přenosu signálu v rostlinách: síť interakcí příjímačové domény histidinkinas u Arabidospis (Acronym: HKRD-AHP) Investor: Czech Science Foundation
GA521/09/1699, research and development project	Name: Imunomodulace jako nástroj funkční proteomiky při studiu cytokininové signální dráhy u Arabidopsis thaliana Investor: Czech Science Foundation, Immunomodulation as a functional proteomics tool for cytokinin signaling study in Arabidopsis thaliana
LC06034, research and development project	Name: Regulace morfogeneze rostlinných buněk a orgánů Investor: Ministry of Education, Youth and Sports of the CR, Regulation of morphogenesis of plant cells and organs
MSM0021622415, plan (intention)	Name: Molekulární podstata buněčných a tkáňových regulací Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations