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@article{956243, author = {Horák, Jakub and Janda, Lubomír and Pekárová, Blanka and Hejátko, Jan}, article_number = {2}, keywords = {Arabidopsis thaliana; cytokinin; phosphorelay; plant hormone; signal integration; signal specificity; signalling pathway; two-component system}, language = {eng}, issn = {1389-2037}, journal = {CURRENT PROTEIN & PEPTIDE SCIENCE}, title = {Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis}, volume = {12}, year = {2011} }
TY - JOUR ID - 956243 AU - Horák, Jakub - Janda, Lubomír - Pekárová, Blanka - Hejátko, Jan PY - 2011 TI - Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis JF - CURRENT PROTEIN & PEPTIDE SCIENCE VL - 12 IS - 2 SP - 126-136 EP - 126-136 PB - Bentham Science Publishers SN - 13892037 KW - Arabidopsis thaliana KW - cytokinin KW - phosphorelay KW - plant hormone KW - signal integration KW - signal specificity KW - signalling pathway KW - two-component system N2 - Multistep phosphorelay (MSP) pathways mediate a wide spectrum of adaptive responses in plants, including hormonal and abiotic stress regulations. Recent genetic evidence suggests both partial redundancy and possible functional cross-talk on the one hand and a certain level of specificity on the other. Here, we discuss recent achievements improving our understanding of possible molecular mechanisms of specificity in MSP. We consider a certain evolutionary conservation of ancestral two-component signalling systems from bacteria in a process of molecular recognition that, as we have recently shown, could be applied also to a certain extent in the case of plant MSP. Furthermore, we discuss possible roles of kinase and phosphatase activities, kinetics of both these enzymatic reactions, and phosphorylation lifetime. We include also recent findings on the expression specificity of individual members of MSP pathways and, finally, based on our recent findings, we speculate about a possible role of magnesium in regulation of MSP pathways in plants. All these mechanisms could significantly influence specificity and signalling output of the MSP pathways. ER -
HORÁK, Jakub, Lubomír JANDA, Blanka PEKÁROVÁ and Jan HEJÁTKO. Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis. \textit{CURRENT PROTEIN \&{} PEPTIDE SCIENCE}. Bentham Science Publishers, 2011, vol.~12, No~2, p.~126-136. ISSN~1389-2037.
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