Detailed Information on Publication Record
2011
Analysis of Biomolecules through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Employing Nanomaterials
CHEN, Wen-Tsen, Iva TOMALOVÁ, Jan PREISLER and Huan-Tsung CHANGBasic information
Original name
Analysis of Biomolecules through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Employing Nanomaterials
Name in Czech
Analýza Biomolekul Hmotnostní spektrometrií s laserovou desorpcí za účasti nanomateriálů
Authors
CHEN, Wen-Tsen (158 Taiwan), Iva TOMALOVÁ (203 Czech Republic, belonging to the institution), Jan PREISLER (203 Czech Republic, guarantor, belonging to the institution) and Huan-Tsung CHANG (158 Taiwan)
Edition
Journal of the Chinese Chemical Society, Taipei, 2011, 0009-4536
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10406 Analytical chemistry
Country of publisher
Taiwan
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.678
RIV identification code
RIV/00216224:14740/11:00050122
Organization unit
Central European Institute of Technology
UT WoS
000296267600009
Keywords (in Czech)
Nanomateriály, Biomolekuly, Hmotnostní spektrometrie s laserovou desorpcí za účasti povrchu, Zobrazovací hmotnostní spektrometrie
Keywords in English
Nanomaterials; Biomolecules; Surface-assisted laser desorption/ionization mass spectrometry; Mass spectrometry imaging
Tags
Reviewed
Změněno: 31/7/2017 15:05, prof. Mgr. Jan Preisler, Ph.D.
Abstract
V originále
Nanomaterials, primarily nanoparticles (NPs), can serve as an alternative matrix for the analysis of various biomolecules through SALDI MS. SALDI MS has been developed to overcome poor reproducibility and high background in the low mass region commonly occurring in MALDI MS. Various nanomaterials, unmodified or functionalized with recognition ligands, can have a strong affinity toward certain analytes and thus are applicable for their concentration and enrichment from complex biological matrices. In mass spectrometry imaging (MSI), the use of NPs instead of the conventional matrices can improve the spatial resolution up to the cellular level. In this review, the nature of NPs, the methods of sample preparation and approaches for quantitation of biomolecules through SALDI MS are discussed. Practical applications and limitations of SALDI MS employing NPs for separate samples and MSI are mentioned. With regard to the nature of MSI analysis, the use of nanostructured surfaces for MSI is also reflected in this review.
Links
| ED1.1.00/02.0068, research and development project |
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| GCP206/10/J012, research and development project |
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| MSM0021622415, plan (intention) |
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| MUNI/A/0992/2009, interní kód MU |
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