Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures.

NOVÁKOVÁ, Kateřina, Pavel BABICA, Ondřej ADAMOVSKÝ and Luděk BLÁHA. Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures. Toxicon. OXFORD, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD, 2011, vol. 58, No 1, p. 76-84. ISSN 0041-0101. Available from: https://dx.doi.org/10.1016/j.toxicon.2011.05.006.

Basic information

• Original name: Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures.
• Authors: NOVÁKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Pavel BABICA (203 Czech Republic), Ondřej ADAMOVSKÝ (203 Czech Republic, belonging to the institution) and Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Toxicon, OXFORD, ENGLAND, PERGAMON-ELSEVIER SCIENCE LTD, 2011, 0041-0101.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30304 Public and environmental health
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.508
• RIV identification code: RIV/00216224:14310/11:00050129
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.toxicon.2011.05.006
• UT WoS: 000294031000010
• Keywords in English: Gap-junctional intercellular communication (GJIC); Exudate; Biomass; Cyanobacteria; Tumor promotion
• Tags: AKR, rivok

Abstract

The extracts from different natural water blooms inhibited GJIC with different potencies without apparent relation to bloom-species composition. Since the observed effects on GJIC did not correlate with the content of cyanotoxins microcystins and cylindrospermopsin in the tested samples, they were most likely induced by unknown compound(s). Our results indicate that putative tumor promoting compound(s) could be associated with different species of bloom-forming cyanobacteria, but their production is probably species- and strain-specific.

Abstract (in Czech)

Extrakty řady sinic a přírodních kultur inhibovaly GJIC v dávkové závislosti. Efekty byly pozorovány také u řas. Výsledky opakovaně ukazují na přítomnost potenciálně nádorově promočních látek, které doposud nebyly charakterizovány, v sinicích a fotoautotrofních organismech.

Links

• ED0001/01/01, research and development project: Name: CETOCOEN
• GA524/08/0496, research and development project: Name: Mechanismy nádorové promoce metabolitů toxických sinic

Investor: Czech Science Foundation, Tumor promotional mechanisms of cyanobacterial metabolites

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)