J 2011

Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures.

NOVÁKOVÁ, Kateřina, Pavel BABICA, Ondřej ADAMOVSKÝ and Luděk BLÁHA

Basic information

Original name

Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures.

Authors

NOVÁKOVÁ, Kateřina (203 Czech Republic, belonging to the institution), Pavel BABICA (203 Czech Republic), Ondřej ADAMOVSKÝ (203 Czech Republic, belonging to the institution) and Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Toxicon, OXFORD, ENGLAND, PERGAMON-ELSEVIER SCIENCE LTD, 2011, 0041-0101

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.508

RIV identification code

RIV/00216224:14310/11:00050129

Organization unit

Faculty of Science

DOI

UT WoS

000294031000010

Keywords in English

Gap-junctional intercellular communication (GJIC); Exudate; Biomass; Cyanobacteria; Tumor promotion

Tags

Změněno: 20/4/2012 11:28, Ing. Andrea Mikešková

Abstract

ORIG CZ

V originále

The extracts from different natural water blooms inhibited GJIC with different potencies without apparent relation to bloom-species composition. Since the observed effects on GJIC did not correlate with the content of cyanotoxins microcystins and cylindrospermopsin in the tested samples, they were most likely induced by unknown compound(s). Our results indicate that putative tumor promoting compound(s) could be associated with different species of bloom-forming cyanobacteria, but their production is probably species- and strain-specific.

In Czech

Extrakty řady sinic a přírodních kultur inhibovaly GJIC v dávkové závislosti. Efekty byly pozorovány také u řas. Výsledky opakovaně ukazují na přítomnost potenciálně nádorově promočních látek, které doposud nebyly charakterizovány, v sinicích a fotoautotrofních organismech.

Links

ED0001/01/01, research and development project
Name: CETOCOEN
GA524/08/0496, research and development project
Name: Mechanismy nádorové promoce metabolitů toxických sinic
Investor: Czech Science Foundation, Tumor promotional mechanisms of cyanobacterial metabolites
MSM0021622412, plan (intention)
Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)
Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)