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@proceedings{958904,
author = {Juřica, Jan and Barteček, Richard and Zendulka, Ondřej and Kašpárek, Tomáš and Pindurová, Eva and Šulcová, Alexandra},
booktitle = {The 61th Czech-Slovak Pharmacological days and EPHAR symposium},
keywords = {CYP2D6; genotype; phenotype; schizophrenia},
language = {cze},
isbn = {978-80-7399-770-0},
title = {CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment},
year = {2011}
}
TY - CONF
ID - 958904
AU - Juřica, Jan - Barteček, Richard - Zendulka, Ondřej - Kašpárek, Tomáš - Pindurová, Eva - Šulcová, Alexandra
PY - 2011
TI - CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment
SN - 9788073997700
KW - CYP2D6
KW - genotype
KW - phenotype
KW - schizophrenia
N2 - Cytochrome P450, namely CYP2D6 is major metabolizing enzyme for many antipsychotics, including risperidone. The aim of present study was to evaluate in 35 patients with first episode of schizophrenia relation of genotype and phenotype of CYP2D6 to therapeutic response to risperidone treatment and occurrence of adverse effects. PANSS score was assessed weekly; as response was considered at least 30 % reduction of baseline of total PANSS score; CYP2D6 genotype was assessed by automatic sequencing of DNA isolated from peripheral leukocytes, phenotype was assessed using dextromethorphan as a probe substrate.
ER -
JUŘICA, Jan, Richard BARTEČEK, Ondřej ZENDULKA, Tomáš KAŠPÁREK, Eva PINDUROVÁ a Alexandra ŠULCOVÁ. CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment. In \textit{The 61th Czech-Slovak Pharmacological days and EPHAR symposium}. ISBN~978-80-7399-770-0. 2011.
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