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@article{958934,
author = {Hladíková, Magdaléna and Vašků, Anna and Štourač, Pavel and Benešová, Yvonne and Bednařík, Josef},
article_number = {1-2},
doi = {http://dx.doi.org/10.1016/j.jns.2011.01.020},
keywords = {Multiple sclerosis; Angiotensin converting enzyme; Angiotensinogen; Polymorphism; Neuroinflammation},
language = {eng},
issn = {0022-510X},
journal = {Journal of the Neurological Sciences},
title = {Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate},
volume = {303},
year = {2011}
}
TY - JOUR
ID - 958934
AU - Hladíková, Magdaléna - Vašků, Anna - Štourač, Pavel - Benešová, Yvonne - Bednařík, Josef
PY - 2011
TI - Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate
JF - Journal of the Neurological Sciences
VL - 303
IS - 1-2
SP - 31-34
EP - 31-34
PB - Elsevier Science
SN - 0022510X
KW - Multiple sclerosis
KW - Angiotensin converting enzyme
KW - Angiotensinogen
KW - Polymorphism
KW - Neuroinflammation
N2 - A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.
ER -
HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ a Josef BEDNAŘÍK. Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate. \textit{Journal of the Neurological Sciences}. Elsevier Science, roč.~303, 1-2, s.~31-34. ISSN~0022-510X. doi:10.1016/j.jns.2011.01.020. 2011.
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