HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ and Josef BEDNAŘÍK. Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate. Journal of the Neurological Sciences. Elsevier Science, 2011, vol. 303, 1-2, p. 31-34. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.01.020. |
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@article{958934, author = {Hladíková, Magdaléna and Vašků, Anna and Štourač, Pavel and Benešová, Yvonne and Bednařík, Josef}, article_number = {1-2}, doi = {http://dx.doi.org/10.1016/j.jns.2011.01.020}, keywords = {Multiple sclerosis; Angiotensin converting enzyme; Angiotensinogen; Polymorphism; Neuroinflammation}, language = {eng}, issn = {0022-510X}, journal = {Journal of the Neurological Sciences}, title = {Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate}, volume = {303}, year = {2011} }
TY - JOUR ID - 958934 AU - Hladíková, Magdaléna - Vašků, Anna - Štourač, Pavel - Benešová, Yvonne - Bednařík, Josef PY - 2011 TI - Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate JF - Journal of the Neurological Sciences VL - 303 IS - 1-2 SP - 31-34 EP - 31-34 PB - Elsevier Science SN - 0022510X KW - Multiple sclerosis KW - Angiotensin converting enzyme KW - Angiotensinogen KW - Polymorphism KW - Neuroinflammation N2 - A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed. ER -
HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ and Josef BEDNAŘÍK. Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate. \textit{Journal of the Neurological Sciences}. Elsevier Science, 2011, vol.~303, 1-2, p.~31-34. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.01.020.
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