Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ and Josef BEDNAŘÍK. Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate. Journal of the Neurological Sciences. Elsevier Science, 2011, vol. 303, 1-2, p. 31-34. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.01.020.

Basic information

• Original name: Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate
• Authors: HLADÍKOVÁ, Magdaléna (203 Czech Republic, guarantor, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution), Yvonne BENEŠOVÁ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution).
• Edition: Journal of the Neurological Sciences, Elsevier Science, 2011, 0022-510X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30211 Orthopaedics
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.353
• RIV identification code: RIV/00216224:14740/11:00054011
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.jns.2011.01.020
• UT WoS: 000289339900004
• Keywords in English: Multiple sclerosis; Angiotensin converting enzyme; Angiotensinogen; Polymorphism; Neuroinflammation
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.