Two frequent polymorphisms of angiotensinogen and their
association with multiple sclerosis progression rate

J 2011

Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ, Josef BEDNAŘÍK et. al.

Basic information

Original name

Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

Authors

HLADÍKOVÁ, Magdaléna (203 Czech Republic, guarantor, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution), Yvonne BENEŠOVÁ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Journal of the Neurological Sciences, Elsevier Science, 2011, 0022-510X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30211 Orthopaedics

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.353

RIV identification code

RIV/00216224:14740/11:00054011

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.jns.2011.01.020

UT WoS

000289339900004

Keywords in English

Multiple sclerosis; Angiotensin converting enzyme; Angiotensinogen; Polymorphism; Neuroinflammation

Abstract

V originále

A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ and Josef BEDNAŘÍK. Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate. Journal of the Neurological Sciences. Elsevier Science, 2011, vol. 303, 1-2, p. 31-34. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.01.020.

@article{958934,
   author = {Hladíková, Magdaléna and Vašků, Anna and Štourač, Pavel and Benešová, Yvonne and Bednařík, Josef},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2011.01.020},
   keywords = {Multiple sclerosis; Angiotensin converting enzyme; Angiotensinogen; Polymorphism; Neuroinflammation},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the Neurological Sciences},
   title = {Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate},
   volume = {303},
   year = {2011}
}

TY  - JOUR
ID  - 958934
AU  - Hladíková, Magdaléna - Vašků, Anna - Štourač, Pavel - Benešová, Yvonne - Bednařík, Josef
PY  - 2011
TI  - Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate
JF  - Journal of the Neurological Sciences
VL  - 303
IS  - 1-2
SP  - 31-34
EP  - 31-34
PB  - Elsevier Science
SN  - 0022510X
KW  - Multiple sclerosis
KW  - Angiotensin converting enzyme
KW  - Angiotensinogen
KW  - Polymorphism
KW  - Neuroinflammation
N2  - A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.
ER  -

HLADÍKOVÁ, Magdaléna, Anna VAŠKŮ, Pavel ŠTOURAČ, Yvonne BENEŠOVÁ and Josef BEDNAŘÍK. Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate. \textit{Journal of the Neurological Sciences}. Elsevier Science, 2011, vol.~303, 1-2, p.~31-34. ISSN~0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.01.020.

Detailed Information on Publication Record