Is the Cerebellum a Potential Target for Stimulation in
Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor
Tasks

J 2011

Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks

MINKS, Eduard, Radek MAREČEK, Tomáš PAVLÍK, Petra OVESNÁ, Martin BAREŠ et. al.

Basic information

Original name

Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks

Authors

MINKS, Eduard (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution)

Edition

Cerebellum, 2011, 1473-4222

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.207

RIV identification code

RIV/00216224:14110/11:00054073

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12311-011-0290-1

UT WoS

000297123900018

Keywords in English

Cerebellum; Motor system; Parkinson's disease; rTMS;TMS;Transcranial magnetic stimulation

Abstract

V originále

The aim of this study was to find whether 1-Hz cerebellar repetitive transcranial magnetic stimulation (rTMS) could affect upper limb movement in early-stage Parkinson's disease (PD). Twenty patients with PD underwent one session with real and one with sham rTMS. rTMS (1 Hz, 600 pulses) was targeted at the right lateral cerebellum. Before and after rTMS, patients performed two motor tests with their fingers and hands (ball test, nine-hole peg test). The duration of these tests was measured. There were statistically significant differences (p<0.05) in the results of the tests after real stimulation and sham stimulation. We excluded the impact of learning. After real rTMS, we observed a significantly faster response in the ball test and a slower response in the nine-hole peg test, both on the right upper limb. This study indicates the influence of 1-Hz cerebellar rTMS in modifying the voluntary movements of the upper limb in PD. This influence is differentiated: the improvement of gross motor skills and the worsening of fine motor skills.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

MINKS, Eduard, Radek MAREČEK, Tomáš PAVLÍK, Petra OVESNÁ and Martin BAREŠ. Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks. Cerebellum. 2011, vol. 10, No 4, p. 804–811. ISSN 1473-4222. Available from: https://dx.doi.org/10.1007/s12311-011-0290-1.

@article{959849,
   author = {Minks, Eduard and Mareček, Radek and Pavlík, Tomáš and Ovesná, Petra and Bareš, Martin},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s12311-011-0290-1},
   keywords = {Cerebellum; Motor system; Parkinson's disease; rTMS;TMS;Transcranial magnetic stimulation},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks},
   volume = {10},
   year = {2011}
}

TY  - JOUR
ID  - 959849
AU  - Minks, Eduard - Mareček, Radek - Pavlík, Tomáš - Ovesná, Petra - Bareš, Martin
PY  - 2011
TI  - Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks
JF  - Cerebellum
VL  - 10
IS  - 4
SP  - 804–811
EP  - 804–811
SN  - 14734222
KW  - Cerebellum
KW  - Motor system
KW  - Parkinson's disease
KW  - rTMS;TMS;Transcranial magnetic stimulation
N2  - The aim of this study was to find whether 1-Hz cerebellar repetitive transcranial magnetic stimulation (rTMS) could affect upper limb movement in early-stage Parkinson's disease (PD). Twenty patients with PD underwent one session with real and one with sham rTMS. rTMS (1 Hz, 600 pulses) was targeted at the right lateral cerebellum. Before and after rTMS, patients performed two motor tests with their fingers and hands (ball test, nine-hole peg test). The duration of these tests was measured. There were statistically significant differences (p<0.05) in the results of the tests after real stimulation and sham stimulation. We excluded the impact of learning. After real rTMS, we observed a significantly faster response in the ball test and a slower response in the nine-hole peg test, both on the right upper limb. This study indicates the influence of 1-Hz cerebellar rTMS in modifying the voluntary movements of the upper limb in PD. This influence is differentiated: the improvement of gross motor skills and the worsening of fine motor skills.
ER  -

MINKS, Eduard, Radek MAREČEK, Tomáš PAVLÍK, Petra OVESNÁ and Martin BAREŠ. Is the Cerebellum a Potential Target for Stimulation in Parkinson's Disease? Results of 1-Hz rTMS on Upper Limb Motor Tasks. \textit{Cerebellum}. 2011, vol.~10, No~4, p.~804–811. ISSN~1473-4222. Available from: https://dx.doi.org/10.1007/s12311-011-0290-1.

Detailed Information on Publication Record