| HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ a L. WEITEROVÁ. A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice. Radiation Research. 2011, roč. 176, č. 2, s. 269-272. ISSN 0033-7587. Dostupné z: https://dx.doi.org/10.1667/RR2614.1. |
Další formáty:
BibTeX
LaTeX
RIS
@article{959950,
author = {Hofer, M. and Pospíšil, M. and Dušek, Ladislav and Hoferová, Z. and Weiterová, L.},
article_number = {2},
doi = {http://dx.doi.org/10.1667/RR2614.1},
keywords = {GAMMA-IRRADIATION; HEMATOPOIETIC RECOVERY; G-CSF; INDOMETHACIN; TOXICITY},
language = {eng},
issn = {0033-7587},
journal = {Radiation Research},
title = {A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice},
volume = {176},
year = {2011}
}
TY - JOUR
ID - 959950
AU - Hofer, M. - Pospíšil, M. - Dušek, Ladislav - Hoferová, Z. - Weiterová, L.
PY - 2011
TI - A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice
JF - Radiation Research
VL - 176
IS - 2
SP - 269-272
EP - 269-272
SN - 00337587
KW - GAMMA-IRRADIATION
KW - HEMATOPOIETIC RECOVERY
KW - G-CSF
KW - INDOMETHACIN
KW - TOXICITY
N2 - This study extends earlier findings of the authors demonstrating that meloxicam, a selective inhibitor of cyclooxygenase 2, supports hematopoietic recovery in sublethally irradiated mice and is radioprotective when given before irradiation. We report here that when meloxicam was administered in a single dose 1 h after a lethal 9-Gy whole-body dose, an increased 30-day survival was achieved. Additional studies showed that administration of meloxicam 24 h after lethal irradiation is ineffective and its repeated administration deleterious. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed.
ER -
HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ a L. WEITEROVÁ. A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice. \textit{Radiation Research}. 2011, roč.~176, č.~2, s.~269-272. ISSN~0033-7587. Dostupné z: https://dx.doi.org/10.1667/RR2614.1.
|
