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@article{959958,
author = {Křízková, Soňa and Zítka, Ondřej and Masařík, Michal and Adam, Vojtěch and Stiborová, Marie and Eckschlager, Tomáš and Chavis, Grace J. and Kizek, René},
article_number = {11},
doi = {http://dx.doi.org/10.1016/j.trac.2011.06.016},
keywords = {Activity-based profiling; Cancer; Disease marker; Enzymatic method; Fluorimetric method; Immunochemical method; In-vivo imaging; Matrix metalloproteinase (MMP); Multiple-enzyme/multiple-reagent assay system (MEMRAS); Phage display},
language = {eng},
issn = {0165-9936},
journal = {Trends in Analytical Chemistry},
title = {Assays for determination of matrix metalloproteinases and their activity},
volume = {30},
year = {2011}
}
TY - JOUR
ID - 959958
AU - Křízková, Soňa - Zítka, Ondřej - Masařík, Michal - Adam, Vojtěch - Stiborová, Marie - Eckschlager, Tomáš - Chavis, Grace J. - Kizek, René
PY - 2011
TI - Assays for determination of matrix metalloproteinases and their activity
JF - Trends in Analytical Chemistry
VL - 30
IS - 11
SP - 1819-1832
EP - 1819-1832
SN - 01659936
KW - Activity-based profiling
KW - Cancer
KW - Disease marker
KW - Enzymatic method
KW - Fluorimetric method
KW - Immunochemical method
KW - In-vivo imaging
KW - Matrix metalloproteinase (MMP)
KW - Multiple-enzyme/multiple-reagent assay system (MEMRAS)
KW - Phage display
N2 - Matrix metalloproteinases (MMPs) are involved in many physiological and pathological processes. Due to their ability to cleave and to remodel components of surrounding tissues, MMPs may affect cell migration, differentiation, growth, inflammatory processes, neovascularization, wound healing, apoptosis, the uterine cycle and many other actions within the body, including those needed for tumorigenesis and other diseases. MMPs can therefore be used as potential markers for detecting various cancers, neurodegenerative, and immune and cardiovascular diseases. Numerous MMP assays were developed for clinical and research purposes, but far more attention has been devoted to understanding their biological functions. Due to differences in methodology, results obtained in various laboratory settings are difficult to compare because of the lack of standards and analyticalmethods of validation. Limits of detection of particularmethods used for identifyingMMPs are also disputable. Enzymatic, immunochemical and fluorimetric methods are particularly suitable for clinical use. In-vivo imaging methods offer many potential advantages in cancer research and diagnostics. Other methods are subject to investigation [e.g., phage display, multiple-enzyme/multiple-reagent assay system (MEMRAS) and activity-based profiling].
ER -
KŘÍZKOVÁ, Soňa, Ondřej ZÍTKA, Michal MASAŘÍK, Vojtěch ADAM, Marie STIBOROVÁ, Tomáš ECKSCHLAGER, Grace J. CHAVIS and René KIZEK. Assays for determination of matrix metalloproteinases and their activity. \textit{Trends in Analytical Chemistry}. 2011, vol.~30, No~11, p.~1819-1832. ISSN~0165-9936. Available from: https://dx.doi.org/10.1016/j.trac.2011.06.016.
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