| ŠULÁK, Ondřej, Gianluca CIOCI, Emilie LAMEIGNÈRE, Viviane BALLOY, Adam ROUND, Irina GUTSCHE, Lenka MALINOVSKÁ, Michel CHIGNARD, Paul KOSMA, Daniel F AUBERT, Cristina L MAROLDA, Miguel A VALVANO, Michaela WIMMEROVÁ and Anne IMBERTY. Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity. PLoS Pathogens. PUBLIC LIBRARY SCIENCE, 2011, vol. 7, No 9, p. "nestránkováno", 14 pp. ISSN 1553-7366. Available from: https://dx.doi.org/10.1371/journal.ppat.1002238. |
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@article{960236,
author = {Šulák, Ondřej and Cioci, Gianluca and Lameignère, Emilie and Balloy, Viviane and Round, Adam and Gutsche, Irina and Malinovská, Lenka and Chignard, Michel and Kosma, Paul and Aubert, Daniel F and Marolda, Cristina L and Valvano, Miguel A and Wimmerová, Michaela and Imberty, Anne},
article_number = {9},
doi = {http://dx.doi.org/10.1371/journal.ppat.1002238},
keywords = {bacterial lectin;Burkholderia cenocepacia;calcium-dependent bacterial lectins;TNF;inflammation},
language = {eng},
issn = {1553-7366},
journal = {PLoS Pathogens},
title = {Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity},
url = {http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002238},
volume = {7},
year = {2011}
}
TY - JOUR
ID - 960236
AU - Šulák, Ondřej - Cioci, Gianluca - Lameignère, Emilie - Balloy, Viviane - Round, Adam - Gutsche, Irina - Malinovská, Lenka - Chignard, Michel - Kosma, Paul - Aubert, Daniel F - Marolda, Cristina L - Valvano, Miguel A - Wimmerová, Michaela - Imberty, Anne
PY - 2011
TI - Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity
JF - PLoS Pathogens
VL - 7
IS - 9
SP - "nestránkováno"
EP - "nestránkováno"
PB - PUBLIC LIBRARY SCIENCE
SN - 15537366
KW - bacterial lectin;Burkholderia cenocepacia;calcium-dependent bacterial lectins;TNF;inflammation
UR - http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002238
L2 - http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002238
N2 - Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia. The N-terminal domain is a novel TNF-a-like fucosebinding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. The C-terminal domain displays specificity for mannose and L-glycero-D-manno-heptose. BC2L-C is therefore a superlectin that binds independently to mannose/heptose glycoconjugates and fucosylated human histo-blood group epitopes. We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. The TNF-a-like domain triggers IL-8 production in cultured airway epithelial cells in a carbohydrate-independent manner, and is therefore proposed to play a role in the dysregulated proinflammatory response observed in B. cenocepacia lung infections.
ER -
ŠULÁK, Ondřej, Gianluca CIOCI, Emilie LAMEIGNÈRE, Viviane BALLOY, Adam ROUND, Irina GUTSCHE, Lenka MALINOVSKÁ, Michel CHIGNARD, Paul KOSMA, Daniel F AUBERT, Cristina L MAROLDA, Miguel A VALVANO, Michaela WIMMEROVÁ and Anne IMBERTY. Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity. \textit{PLoS Pathogens}. PUBLIC LIBRARY SCIENCE, 2011, vol.~7, No~9, p.~''nestránkováno'', 14 pp. ISSN~1553-7366. Available from: https://dx.doi.org/10.1371/journal.ppat.1002238.
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