Whole Genome Analyses of Treponemes: New Targets for Strain-
and Subspecies- Specific Molecular Diagnostics

C 2011

Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics

ŠMAJS, David, Lenka MIKALOVÁ, Darina ČEJKOVÁ, Michal STROUHAL, Marie ZOBANÍKOVÁ et. al.

Basic information

Original name

Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics

Authors

ŠMAJS, David (203 Czech Republic, guarantor, belonging to the institution), Lenka MIKALOVÁ (203 Czech Republic, belonging to the institution), Darina ČEJKOVÁ (203 Czech Republic, belonging to the institution), Michal STROUHAL (203 Czech Republic, belonging to the institution), Marie ZOBANÍKOVÁ (203 Czech Republic, belonging to the institution), Petra POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Steven J. NORRIS (840 United States of America) and George M. WEINSTOCK (840 United States of America)

Edition

Rijeka (Croatia), Syphilis - Recognition, Description and Diagnosis, p. 19-34, 16 pp. Infectious Diseases, 2011

Publisher

InTech

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

10600 1.6 Biological sciences

Country of publisher

Croatia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/11:00050208

Organization unit

Faculty of Medicine

ISBN

978-953-307-554-9

Keywords in English

genus Treponema; syphilis

Abstract

V originále

The genus Treponema comprises several human uncultivable pathogens including Treponema pallidum subspecies pallidum (TPA, the causative agent of the sexually transmitted syphilis), Treponema pallidum subspecies pertenue (TPE, causative agent of yaws), Treponema pallidum subspecies endemicum (TEN, causing endemic syphilis), and Treponema carateum causing pinta. Additionally, the rabbit pathogen Treponema paraluiscuniculi (TPC) is very similar to syphilis treponeme but is not pathogenic to humans. Other pathogenic treponemes (e.g. Treponema denticola and T. vincentii) differ from the others by having considerably larger genomes. Moreover, these treponemes can be cultivated under in vitro conditions. The infections caused by human uncultivable pathogenic treponemes can be classified according to their invasivity, from the most invasive bacterium causing venereal syphilis to Treponema carateum (pinta), which is a non- invasive spirochete causing local dermal lesions. Strains of non-venereal treponemes including Treponema pallidum subspecies pertenue and endemicum are considered moderately invasive.

Links

GA310/07/0321, research and development project

Name: Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

Investor: Czech Science Foundation

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

NT11159, research and development project

Name: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Investor: Ministry of Health of the CR

Citovat

ŠMAJS, David, Lenka MIKALOVÁ, Darina ČEJKOVÁ, Michal STROUHAL, Marie ZOBANÍKOVÁ, Petra POSPÍŠILOVÁ, Steven J. NORRIS and George M. WEINSTOCK. Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics. In Syphilis - Recognition, Description and Diagnosis. Rijeka (Croatia): InTech, 2011, p. 19-34. Infectious Diseases. ISBN 978-953-307-554-9.

@inbook{961064,
   author = {Šmajs, David and Mikalová, Lenka and Čejková, Darina and Strouhal, Michal and Zobaníková, Marie and Pospíšilová, Petra and Norris, Steven J. and Weinstock, George M.},
   address = {Rijeka (Croatia)},
   booktitle = {Syphilis - Recognition, Description and Diagnosis},
   keywords = {genus Treponema; syphilis},
   language = {eng},
   location = {Rijeka (Croatia)},
   isbn = {978-953-307-554-9},
   pages = {19-34},
   publisher = {InTech},
   title = {Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics},
   url = {http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf},
   year = {2011}
}

TY  - CHAP
ID  - 961064
AU  - Šmajs, David - Mikalová, Lenka - Čejková, Darina - Strouhal, Michal - Zobaníková, Marie - Pospíšilová, Petra - Norris, Steven J. - Weinstock, George M.
PY  - 2011
TI  - Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics
VL  - Infectious Diseases
PB  - InTech
CY  - Rijeka (Croatia)
SN  - 9789533075549
KW  - genus Treponema
KW  - syphilis
UR  - http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf
L2  - http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf
N2  - The genus Treponema comprises several human uncultivable pathogens including Treponema pallidum subspecies pallidum (TPA, the causative agent of the sexually transmitted syphilis), Treponema pallidum subspecies pertenue (TPE, causative agent of yaws), Treponema pallidum subspecies endemicum (TEN, causing endemic syphilis), and Treponema carateum causing pinta. Additionally, the rabbit pathogen Treponema paraluiscuniculi (TPC) is very similar to syphilis treponeme but is not pathogenic to humans. Other pathogenic treponemes (e.g. Treponema denticola and T. vincentii) differ from the others by having considerably larger genomes. Moreover, these treponemes can be cultivated under in vitro conditions. The infections caused by human uncultivable pathogenic treponemes can be classified according to their invasivity, from the most invasive bacterium causing venereal syphilis to Treponema carateum (pinta), which is a non- invasive spirochete causing local dermal lesions. Strains of non-venereal treponemes including Treponema pallidum subspecies pertenue and endemicum are considered moderately invasive.
ER  -

ŠMAJS, David, Lenka MIKALOVÁ, Darina ČEJKOVÁ, Michal STROUHAL, Marie ZOBANÍKOVÁ, Petra POSPÍŠILOVÁ, Steven J. NORRIS and George M. WEINSTOCK. Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics. In \textit{Syphilis - Recognition, Description and Diagnosis}. Rijeka (Croatia): InTech, 2011, p.~19-34. Infectious Diseases. ISBN~978-953-307-554-9.

Detailed Information on Publication Record