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@inbook{961064,
author = {Šmajs, David and Mikalová, Lenka and Čejková, Darina and Strouhal, Michal and Zobaníková, Marie and Pospíšilová, Petra and Norris, Steven J. and Weinstock, George M.},
address = {Rijeka (Croatia)},
booktitle = {Syphilis - Recognition, Description and Diagnosis},
keywords = {genus Treponema; syphilis},
language = {eng},
location = {Rijeka (Croatia)},
isbn = {978-953-307-554-9},
pages = {19-34},
publisher = {InTech},
title = {Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics},
url = {http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf},
year = {2011}
}
TY - CHAP
ID - 961064
AU - Šmajs, David - Mikalová, Lenka - Čejková, Darina - Strouhal, Michal - Zobaníková, Marie - Pospíšilová, Petra - Norris, Steven J. - Weinstock, George M.
PY - 2011
TI - Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics
VL - Infectious Diseases
PB - InTech
CY - Rijeka (Croatia)
SN - 9789533075549
KW - genus Treponema
KW - syphilis
UR - http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf
L2 - http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf
N2 - The genus Treponema comprises several human uncultivable pathogens including Treponema pallidum subspecies pallidum (TPA, the causative agent of the sexually transmitted syphilis), Treponema pallidum subspecies pertenue (TPE, causative agent of yaws), Treponema pallidum subspecies endemicum (TEN, causing endemic syphilis), and Treponema carateum causing pinta. Additionally, the rabbit pathogen Treponema paraluiscuniculi (TPC) is very similar to syphilis treponeme but is not pathogenic to humans. Other pathogenic treponemes (e.g. Treponema denticola and T. vincentii) differ from the others by having considerably larger genomes. Moreover, these treponemes can be cultivated under in vitro conditions. The infections caused by human uncultivable pathogenic treponemes can be classified according to their invasivity, from the most invasive bacterium causing venereal syphilis to Treponema carateum (pinta), which is a non- invasive spirochete causing local dermal lesions. Strains of non-venereal treponemes including Treponema pallidum subspecies pertenue and endemicum are considered moderately invasive.
ER -
ŠMAJS, David, Lenka MIKALOVÁ, Darina ČEJKOVÁ, Michal STROUHAL, Marie ZOBANÍKOVÁ, Petra POSPÍŠILOVÁ, Steven J. NORRIS and George M. WEINSTOCK. Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics. In \textit{Syphilis - Recognition, Description and Diagnosis}. Rijeka (Croatia): InTech, 2011, p.~19-34. Infectious Diseases. ISBN~978-953-307-554-9.
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