KAUCKÁ, Markéta, Pavel KREJČÍ, Karla PLEVOVÁ, Šárka PAVLOVÁ, Jiřina PROCHÁZKOVÁ, Pavlína JANOVSKÁ, Jana VALNOHOVÁ, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ a Vítězslav BRYJA. Post-translational modifications regulate signalling by Ror1. Acta Physiologica. Oxford: Blackwell Publishing, 2011, roč. 203, č. 3, s. 351-362. ISSN 1748-1708. Dostupné z: https://dx.doi.org/10.1111/j.1748-1716.2011.02306.x. |
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@article{961182, author = {Kaucká, Markéta and Krejčí, Pavel and Plevová, Karla and Pavlová, Šárka and Procházková, Jiřina and Janovská, Pavlína and Valnohová, Jana and Kozubík, Alois and Pospíšilová, Šárka and Bryja, Vítězslav}, article_location = {Oxford}, article_number = {3}, doi = {http://dx.doi.org/10.1111/j.1748-1716.2011.02306.x}, keywords = {Ror1; posttranslational modifications; glycosylation; chronic lymphocytic leukemia}, language = {eng}, issn = {1748-1708}, journal = {Acta Physiologica}, title = {Post-translational modifications regulate signalling by Ror1}, volume = {203}, year = {2011} }
TY - JOUR ID - 961182 AU - Kaucká, Markéta - Krejčí, Pavel - Plevová, Karla - Pavlová, Šárka - Procházková, Jiřina - Janovská, Pavlína - Valnohová, Jana - Kozubík, Alois - Pospíšilová, Šárka - Bryja, Vítězslav PY - 2011 TI - Post-translational modifications regulate signalling by Ror1 JF - Acta Physiologica VL - 203 IS - 3 SP - 351-362 EP - 351-362 PB - Blackwell Publishing SN - 17481708 KW - Ror1 KW - posttranslational modifications KW - glycosylation KW - chronic lymphocytic leukemia N2 - Ror1 (receptor tyrosine kinase-like orphan receptor)is highly upregulated in B cells of patients with chronic lymphocytic leukaemia (CLL). Ror1 acts as the Wnt receptor in the non-canonical Wnt pathway. We demonstrate that Ror1 is extensively modified by N-linked glycosylation. Glycosylation produces several variants of Ror1 with electrophoretic migration of approx. 100, 115 and 130 kDa. Inhibition of glycosylation interferes with cell surface localization of the 130-kDa variant of Ror1 and prevents Ror1-induced formation of filopodia. Moreover, we show that 130-kDa Ror1 is mono-ubiquitinated. Furthermore, individual CLL patients show striking differences in the electrophoretic migration of Ror1, which correspond to the level of glycosylation. Our data show that Ror1 undergoes complex post-translational modifications by glycosylation and mono-ubiquitination. These modifications regulate Ror1 localization and signalling, and are highly variable among individual CLL patients. These may suggest that Ror1 signals only in a subset of CLL patients despite Ror1 levels are ubiquitously high in all CLL patients. ER -
KAUCKÁ, Markéta, Pavel KREJČÍ, Karla PLEVOVÁ, Šárka PAVLOVÁ, Jiřina PROCHÁZKOVÁ, Pavlína JANOVSKÁ, Jana VALNOHOVÁ, Alois KOZUBÍK, Šárka POSPÍŠILOVÁ a Vítězslav BRYJA. Post-translational modifications regulate signalling by Ror1. \textit{Acta Physiologica}. Oxford: Blackwell Publishing, 2011, roč.~203, č.~3, s.~351-362. ISSN~1748-1708. Dostupné z: https://dx.doi.org/10.1111/j.1748-1716.2011.02306.x.
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