Effect of Electroconvulsive Therapy on Cortical Excitability in
a patient With Long-Term Remission of Schizophrenia: A
Transcranial Magnetic Stimulation Study

J 2011

Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study

PŘIKRYL, Radovan, Libor USTOHAL, Hana PŘIKRYLOVÁ KUČEROVÁ and Eva ČEŠKOVÁ

Basic information

Original name

Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study

Name in Czech

Vliv elektrokonvulzivní terapie na kortikální agresivitu u pacientů s dlouhodobou epizodou schizofrenie: Studie transkraniální magnetické stimulace

Authors

PŘIKRYL, Radovan (203 Czech Republic, guarantor, belonging to the institution), Libor USTOHAL (203 Czech Republic, belonging to the institution), Hana PŘIKRYLOVÁ KUČEROVÁ (203 Czech Republic, belonging to the institution) and Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Journal of ECT, USA, Lippincott Williams and Wilkins, 2011, 1095-0680

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.536

RIV identification code

RIV/00216224:14740/11:00054286

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1097/YCT.0b013e3181dbf785

UT WoS

000287697100004

Keywords in English

effect; electroconvulsive therapy; therapy on cortical excitability; remission of schizophrenia

Abstract

V originále

The exact effects of electroconvulsive therapy (ECT) on the brain are still not accurately known. Hypotheses considered include the effect of ECT on cortical excitability of the brain. The aim of this trial was to assess the changes in cortical excitability in the brain of a patient with remitted schizophrenia, undergoing maintenance ECT. Three successive ECT applications resulted in significant prolongation of the cortical silent period, which implies augmentation of inhibitory cortical mechanisms in the brain, most likely mediated by the GABAergic (GABA, gamma-aminobutyric acid) system with direct involvement of GABA(B) receptors. The actual therapeutic effect of ECT is therefore probably due to facilitation of cortical inhibitory mechanisms induced by GABAergic neurotransmission.

Links

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

PŘIKRYL, Radovan, Libor USTOHAL, Hana PŘIKRYLOVÁ KUČEROVÁ and Eva ČEŠKOVÁ. Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study. Journal of ECT. USA: Lippincott Williams and Wilkins, 2011, vol. 27, No 1, p. "E9"-"E11", 3 pp. ISSN 1095-0680. Available from: https://dx.doi.org/10.1097/YCT.0b013e3181dbf785.

@article{961253,
   author = {Přikryl, Radovan and Ustohal, Libor and Přikrylová Kučerová, Hana and Češková, Eva},
   article_location = {USA},
   article_number = {1},
   doi = {http://dx.doi.org/10.1097/YCT.0b013e3181dbf785},
   keywords = {effect; electroconvulsive therapy; therapy on cortical excitability; remission of schizophrenia},
   language = {eng},
   issn = {1095-0680},
   journal = {Journal of ECT},
   title = {Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study},
   volume = {27},
   year = {2011}
}

TY  - JOUR
ID  - 961253
AU  - Přikryl, Radovan - Ustohal, Libor - Přikrylová Kučerová, Hana - Češková, Eva
PY  - 2011
TI  - Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study
JF  - Journal of ECT
VL  - 27
IS  - 1
SP  - "E9"-"E11"
EP  - "E9"-"E11"
PB  - Lippincott Williams and Wilkins
SN  - 10950680
KW  - effect
KW  - electroconvulsive therapy
KW  - therapy on cortical excitability
KW  - remission of schizophrenia
N2  - The exact effects of electroconvulsive therapy (ECT) on the brain are still not accurately known. Hypotheses considered include the effect of ECT on cortical excitability of the brain. The aim of this trial was to assess the changes in cortical excitability in the brain of a patient with remitted schizophrenia, undergoing maintenance ECT. Three successive ECT applications resulted in significant prolongation of the cortical silent period, which implies augmentation of inhibitory cortical mechanisms in the brain, most likely mediated by the GABAergic (GABA, gamma-aminobutyric acid) system with direct involvement of GABA(B) receptors. The actual therapeutic effect of ECT is therefore probably due to facilitation of cortical inhibitory mechanisms induced by GABAergic neurotransmission.
ER  -

PŘIKRYL, Radovan, Libor USTOHAL, Hana PŘIKRYLOVÁ KUČEROVÁ and Eva ČEŠKOVÁ. Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study. \textit{Journal of ECT}. USA: Lippincott Williams and Wilkins, 2011, vol.~27, No~1, p.~''E9''-''E11'', 3 pp. ISSN~1095-0680. Available from: https://dx.doi.org/10.1097/YCT.0b013e3181dbf785.

Detailed Information on Publication Record