Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study

PŘIKRYL, Radovan, Libor USTOHAL, Hana PŘIKRYLOVÁ KUČEROVÁ and Eva ČEŠKOVÁ. Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study. Journal of ECT. USA: Lippincott Williams and Wilkins, 2011, vol. 27, No 1, p. "E9"-"E11", 3 pp. ISSN 1095-0680. Available from: https://dx.doi.org/10.1097/YCT.0b013e3181dbf785.

Basic information

• Original name: Effect of Electroconvulsive Therapy on Cortical Excitability in a patient With Long-Term Remission of Schizophrenia: A Transcranial Magnetic Stimulation Study
• Name in Czech: Vliv elektrokonvulzivní terapie na kortikální agresivitu u pacientů s dlouhodobou epizodou schizofrenie: Studie transkraniální magnetické stimulace
• Authors: PŘIKRYL, Radovan (203 Czech Republic, guarantor, belonging to the institution), Libor USTOHAL (203 Czech Republic, belonging to the institution), Hana PŘIKRYLOVÁ KUČEROVÁ (203 Czech Republic, belonging to the institution) and Eva ČEŠKOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Journal of ECT, USA, Lippincott Williams and Wilkins, 2011, 1095-0680.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.536
• RIV identification code: RIV/00216224:14740/11:00054286
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1097/YCT.0b013e3181dbf785
• UT WoS: 000287697100004
• Keywords in English: effect; electroconvulsive therapy; therapy on cortical excitability; remission of schizophrenia
• Tags: ok, rivok
• Tags: International impact

Abstract

The exact effects of electroconvulsive therapy (ECT) on the brain are still not accurately known. Hypotheses considered include the effect of ECT on cortical excitability of the brain. The aim of this trial was to assess the changes in cortical excitability in the brain of a patient with remitted schizophrenia, undergoing maintenance ECT. Three successive ECT applications resulted in significant prolongation of the cortical silent period, which implies augmentation of inhibitory cortical mechanisms in the brain, most likely mediated by the GABAergic (GABA, gamma-aminobutyric acid) system with direct involvement of GABA(B) receptors. The actual therapeutic effect of ECT is therefore probably due to facilitation of cortical inhibitory mechanisms induced by GABAergic neurotransmission.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.