Multiple Myeloma Associated IgA Pemphigus: Treatment With Bortezomib- and Lenalidomide-Based Regimen

SZTURZ, Petr, Zdeněk ADAM, Mária KLINCOVÁ, Josef FEIT, Marta KREJČÍ, Luděk POUR, Lenka ZAHRADOVÁ, Vladimír VAŠKŮ, Roman HÁJEK and Jiří MAYER. Multiple Myeloma Associated IgA Pemphigus: Treatment With Bortezomib- and Lenalidomide-Based Regimen. Clinical Lymphoma, Myeloma & Leukemia. 2011, vol. 11, No 6, p. 517-520. ISSN 2152-2650. Available from: https://dx.doi.org/10.1016/j.clml.2011.06.014.

Basic information

• Original name: Multiple Myeloma Associated IgA Pemphigus: Treatment With Bortezomib- and Lenalidomide-Based Regimen
• Authors: SZTURZ, Petr (203 Czech Republic, guarantor, belonging to the institution), Zdeněk ADAM (203 Czech Republic, belonging to the institution), Mária KLINCOVÁ (703 Slovakia, belonging to the institution), Josef FEIT (203 Czech Republic, belonging to the institution), Marta KREJČÍ (203 Czech Republic, belonging to the institution), Luděk POUR (203 Czech Republic, belonging to the institution), Lenka ZAHRADOVÁ (203 Czech Republic, belonging to the institution), Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution), Roman HÁJEK (203 Czech Republic, belonging to the institution) and Jiří MAYER (203 Czech Republic, belonging to the institution).
• Edition: Clinical Lymphoma, Myeloma & Leukemia, 2011, 2152-2650.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.880
• RIV identification code: RIV/00216224:14110/11:00054365
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.clml.2011.06.014
• UT WoS: 000298280200010
• Keywords in English: Autoimmunity; Bortezomib; IgA pemphigus; Lenalidomide; Multiple myeloma; Paraproteinemia
• Tags: International impact

Abstract

Generally, monoclonal immunoglobulins do not bind an autologous antigen, except for some cases, when it causes immune damage to body’s own tissues. Vesiculopustulous dermatitis associated with immunoglobulin (Ig) A deposition in the epidermis represents an autoimmune skin manifestation of monoclonal gammopathy. It is commonly referred to as subcorneal pustular dermatosis type of IgA pemphigus.1 In our previous work, we reported on complete and long-term remission of multiple myeloma associated IgA pemphigus after treatment with a bortezomib (Velcade) based regimen.2 In this work, to our knowledge, we are the first to publish a convincing clinical remission and excellent drug tolerance of a subsequent lenalidomide (Revlimid) based regimen used in the same patient for management of the relapsed disease.

Links

• LC06027, research and development project: Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)

Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group

• MSM0021622434, plan (intention): Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií

Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies

• NT11154, research and development project: Name: Úloha mitotické disrupce v B lymfocytech u mnohočetném myelomu

Investor: Ministry of Health of the CR